Results 131 to 140 of about 7,235 (313)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Schützen nützt – Netzwerk Europäische Wildrebe
Julius-Kühn-Archiv, 2020 Nick, Peter
doaj +1 more source
Promotores de crescimento na alimentação de frango de corte: desempenho zootécnico e análise de resíduos (antimicrobianos) na cama de aviário [PDF]
, 2002 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias. Programa de Pós-Graduação em Agroecossistemas.A avicultura industrial brasileira teve seu marco inicial na década de 60, trazendo consigo a utilização de ...
Santos, Ione Iolanda dos
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
, 2021 Aim : Preeclampsia is a global problem that affects 2-8% of all pregnancies. Insulin resistance has long been attributed in preeclampsia pathogenesis and is a significant risk factor. Its also the main diagnostic characteristic in hypertension.
Meritha, Cinthya Ayu
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Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Determination of enzyme induced resistence in clinically significant Gram negative bacterial strains
, 2013 Noteikta K.pneumoniae, P.aeruginosa, A.baumannii un E.coli rezistence pret antibakteriālajiem preparātiem. Darbs izstrādāts RAKUS Tuberkulozes un plaušu slimību centra Mikobakterioloģijas laboratorijā. Izanalizēti materiāli no 2012. gada.
Vēvere, Indra
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Revista da Sociedade Brasileira de Medicina Tropical, 1975 Exemplares de Biomphalaria tenagophila, originários de Londrina, mostraram-se resistentes à infecção por cepa simpátrica de Schistosoma mansoni e por cepa originária de Belo Horizonte (MG).
Pedro P. Chieffi
doaj