Results 81 to 90 of about 8,731 (307)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
The Kop Resistence in Bayburt Folk Poetry
, 2010 Tarihi bir olay yaşandığı dönemle sınırlı değildir. Olayın etkileri zamana yayılır ve değişik sahalarda bu etkiler karşımıza çıkar. Makalemizde Kop Savunması'nın Bayburt Halk Şiirine yansımasını ele aldık.
Kara, Kürşat
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Diacronie. Studi di Storia Contemporanea, 2014 This paper aims to analyze the role and the pattern of the militant lawyering of Leonida Casali, one of the leading members of Bologna section of the Italian Communist Party and of the Democratic Solidarity Committee during the postwar period.
Greta Fedele
doaj
Resisting Bacterial Drug Resistance [PDF]
Chemistry & Biology, 2003 In this issue of Chemistry & Biology, Wright and colleagues report an elegant method for inhibiting enzymes critical for rendering bacteria drug resistant. By using cationic peptides as inhibitors, the authors have exploited two antibacterial mechanisms, making it doubly difficult for microbial retaliation.
openaire +2 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Nostalgia as resistence to oblivion: Three deeds of search in the documentary Nostalgia de la luz [PDF]
, 2018 O objetivo deste artigo é o de empreender uma análise que evidencie como no filme Nostalgia de la Luz (Chile/França/Alemanha, 2010) astrônomos, arqueólogos e mulheres reconstroem, através de suas buscas, acontecimentos trágicos de suas vidas e da ...
Rocha, Simone María
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Academic Journal of Modern PhilologyOur study aims to approach the evolution of female identity and consciousness in two contemporary French-speaking Algerian women writers. In this context, our work will have the plays Rouge l'Aube [The Red Dawn] (1958–1959) by Assia Djebar and Princesses
Christina Oikonomopoulou
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Urological Studies on Patients with Traumatic Spinal Cord Injury. II : Intravesical Pressure and Urethral Resistence with a Reference to Effects of Drugs. [PDF]
, 1964 Measurement of intravesical pressure was performed in 4 3 patients with traumatic spinal cord injury. At the same time, investigation on the method of measurement, experiments of urethral resistance and studies on effects of autonomic nerve drugs upon ...
伊藤, 順勉
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