Results 91 to 100 of about 351,150 (284)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Evaluation of Frequency Effects on Fatigue Life at High Test Frequencies for SAE 1045 Steel Based on Thermography and Electrical Resistance Measurements

Applied Sciences
This research provides a method for a reliable fatigue life estimation at high testing frequencies. The investigations are based on the lifetime prediction method StressLifeHCF considering test frequencies of 80 and 260 Hz for normalized SAE 1045 (C45E ...
Jonas Anton Ziman, Fabian Weber, Janina Koziol, Johannes Leon Otto, Lukas Maximilian Sauer, Frank Walther, Peter Starke   +6 more
doaj   +1 more source

Effects of Lifshitz Transition on Charge Transport in Magnetic Phases of Fe-Based Superconductors

, 2015
The unusual temperature dependence of the resistivity and its in-plane anisotropy observed in the Fe-based superconducting materials, particularly Ba(Fe$_{1-x}$Co$_x$)$_2$As$_2$, has been a longstanding puzzle.
Andersen, Brian M., Gastiasoro, Maria N., Hirschfeld, P. J., Jeschke, Harald O., Paul, Indranil, Tomić, M., Valentí, Roser, Wang, Y.   +7 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Effect of Magnetic Field and Aggregation on Electrical Characteristics of Magnetically Responsive Suspensions for Novel Hybrid Liquid Capacitor

Magnetochemistry, 2019
Magnetically responsive fluid based on polymers of natural rubber (NR-latex) involves a magnetic compound fluid (MCF) rubber liquid. For a wide range of engineering applications of suspensions or liquids with particles, their electrical characteristics ...
Kunio Shimada
doaj   +1 more source

Measurement of electrical properties of electrode materials for the bakelite Resistive Plate Chambers

, 2012
Single gap (gas gap 2 mm) bakelite Resistive Plate Chamber (RPC) modules of various sizes from 10 cm \times 10 cm to 1 m \times 1 m have been fabricated, characterized and optimized for efficiency and time resolution.
, A Banerjee, A. Sharma, ALICE collaboration, ATLAS collaboration, BaBar collaboration, BES-III collaboration, C Marick, CMS collaboration, G Das, K K Meghna, LHCb collaboration, N. Majumdar ., OPERA collaboration, S Bhattacharya, S Biswas, S Bose, S Chattopadhyay, S Saha, S. Biswas, Y P Viyogi   +20 more
core   +1 more source

ANTIBIOTIC RESISTANCE

Critical Care Clinics, 1998
Antibiotic resistance is an increasing problem in many parts of the world. Antibiotic resistance has been associated with the use of some antibiotics but not with others. Due to the overuse of antibiotics with a high resistance potential, there has been an increase of resistance with certain bacteria, e.g., Staphylococcus aureus, Pseudomonas aeruginosa
openaire   +3 more sources