Results 1 to 10 of about 20,725 (257)

Mobile resistome of human gut and pathogen drives anthropogenic bloom of antibiotic resistance [PDF]

Microbiome, 2020
Background The impact of human activities on the environmental resistome has been documented in many studies, but there remains the controversial question of whether the increased antibiotic resistance observed in anthropogenically impacted environments ...
Kihyun Lee, Dae-Wi Kim, Do-Hoon Lee, Yong-Seok Kim, Ji-Hye Bu, Ju-Hee Cha, Cung Nawl Thawng, Eun-Mi Hwang, Hoon Je Seong, Woo Jun Sul, Elizabeth M. H. Wellington, Christopher Quince, Chang-Jun Cha   +12 more
doaj   +2 more sources

Soil-borne legacy facilitates the dissemination of antibiotic resistance genes in soil-plant continua. [PDF]

Imeta
Antimicrobial resistance (AMR) disseminates throughout the soil–plant continuum via complex microbial interactions. Plants shape root‐ and leaf‐associated microbiomes that sustain plant health; however, soil‐borne legacies—enriched with antibiotic‐producing microbes and resistance genes—govern AMR dynamics across agroecosystems.
Xiao Z, Ding K, Guo X, Zhao Y, Li X, Jiang D, Zhu D, Chen Q, Jong MC, Graham DW, Li G, Zhu YG.   +11 more
europepmc   +2 more sources

The Gut Resistome Atlas in Preterm Infants Enables Prediction of Necrotizing Enterocolitis Onset. [PDF]

Adv Sci (Weinh)
The gut resistome of preterm infants and its clinical relevance remain poorly understood. This study performs in‐depth integrative analyses of 5,684 gut metagenomes from preterm infants, uncovering distinct features that diverge from term infants. Notably, the gut resistome of preterm infants converges 9 days before necrotizing enterocolitis onset ...
Zeng S, Wang H, Zhang L, Li S, Yuan Y, Tian M, Qu Y, Ying J, Zhou M, Hu Y, Huang J, Zou R, Zhao F, Su X, Liu Q, He Y, Feng J, Huang W, Luo Y, Zhou Z, Shen W, Mu D, Wang S.   +22 more
europepmc   +2 more sources

Mobilization of Antibiotic Resistance: Are Current Approaches for Colocalizing Resistomes and Mobilomes Useful? [PDF]

Frontiers in Microbiology, 2020
Antimicrobial resistance (AMR) poses a global human and animal health threat, and predicting AMR persistence and transmission remains an intractable challenge.
Ilya B. Slizovskiy, Kingshuk Mukherjee, Christopher J. Dean, Christina Boucher, Noelle R. Noyes   +4 more
doaj   +2 more sources

Breastfeeding and the milk resistome shape the establishment and transmission of antibiotic resistance genes in the infant gut microbiome [PDF]

Gut Microbes
The infant resistome, the collection of antibiotic resistance genes (ARGs) of newborns, is critical for gut microbiota establishment. Using metagenomic sequencing data, we analyzed various 1-week and 1-month postpartum samples to study infant resistome ...
Zhe Pan, Calum J. Walsh, Conor Feehily, Sai Ravi Chandra Nori, Fionnuala M. McAuliffe, Paul D. Cotter, John MacSharry, Douwe van Sinderen   +7 more
doaj   +2 more sources

Inflammatory Endotype-Associated Airway Resistome in Chronic Obstructive Pulmonary Disease

Microbiology Spectrum, 2022
Antimicrobial resistance is a global concern in chronic respiratory diseases, including chronic obstructive pulmonary disease (COPD). The collection of antibiotic resistance genes or resistome in human airways may underlie the resistance.
Xinzhu Yi, Yanjun Li, Haiyue Liu, Xiaomin Liu, Junhao Yang, Jingyuan Gao, Yuqiong Yang, Zhenyu Liang, Fengyan Wang, Dandan Chen, Lingwei Wang, Weijuan Shi, David C. L. Lam, Martin R. Stampfli, Paul W. Jones, Rongchang Chen, Zhang Wang   +16 more
doaj   +1 more source

Colistin-degrading proteases confer collective resistance to microbial communities during polymicrobial infections

Microbiome, 2022
Background The increasing prevalence of resistance against the last-resort antibiotic colistin is a significant threat to global public health. Here, we discovered a novel colistin resistance mechanism via enzymatic inactivation of the drug and proposed ...
Do-Hoon Lee, Ju-Hee Cha, Dae-Wi Kim, Kihyun Lee, Yong-Seok Kim, Hyo-Young Oh, You-Hee Cho, Chang-Jun Cha   +7 more
doaj   +1 more source

Antibiotic resistome in groundwater and its association with mountain springs and river

Ecotoxicology and Environmental Safety, 2023
The distribution of antibiotic resistance genes (ARGs) in water sources potentially threatens drinking water safety. However, the sources of antibiotic resistome in groundwater are still under-investigated.
Fu-Yi Huang, Yi Zhao, Roy Neilson, Xin-Yuan Zhou, Hu Li, Lei Ding, Shu-Yi-Dan Zhou, Jian-Qiang Su   +7 more
doaj   +1 more source

Metagenomic binning and assembled genome analysis revealed the distinct composition of resistome and mobilome in the Ili River

Ecotoxicology and Environmental Safety, 2022
Rivers play an important role in receiving and transporting the resistome among different environmental compartments. However, the difference in resistome and mobilome between the water and sediment and their underlying mechanisms were still poorly ...
Wenjuan Song, Haiyang Chen, Nana Xue, Shuzhi Wang, Yuyi Yang   +4 more
doaj   +1 more source

Transition of antimicrobial resistome in wastewater treatment plants: impact of process configuration, geographical location and season

npj Clean Water, 2023
Antimicrobial resistome in wastewater treatment plants was investigated via shotgun metagenomic analysis over a variety of geographical locations, seasons, and biological treatment configurations.
Ryo Honda, Norihisa Matsuura, Sovannlaksmy Sorn, Sawako Asakura, Yuta Morinaga, Than Van Huy, Muhammad Adnan Sabar, Yalkhin Masakke, Hiroe Hara-Yamamura, Toru Watanabe   +9 more
doaj   +1 more source