Results 231 to 240 of about 19,820 (248)
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The Antibiotic Resistome: Challenge And Opportunity For Therapeutic Intervention
Future Medicinal Chemistry, 2012Despite the relevance of infectious disease as main causes of human morbidity and mortality, the development of new antibacterials is not among the highest priorities for pharmaceutical companies. Regulatory and economic issues, together with the lack of novel targets, might justify the reduced rate of discovery of new antimicrobials.
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Transmission Routes of the Microbiome and Resistome from Manure to Soil and Lettuce
Environmental Science & Technology, 2021Xu Li, Harkamal Walia, Daniel D. Snow
exaly
Metagenomic insights into resistome coalescence in an urban sewage treatment plant-river system
Water Research, 2022Haiyang Chen, Yanguo Teng, Chang Liu
exaly
The resistance within: Antibiotic disruption of the gut microbiome and resistome dynamics in infancy
Cell Host and Microbe, 2022Sanjam S Sawhney +2 more
exaly
Novel antibiotic discovery and the antibiotic resistome
Expert Opinion on Drug DiscoveryThe success of antibiotics in the therapy of infectious diseases is overshadowed by almost inevitable emergence and dissemination of resistances toward these agents, which results in higher morbidity and mortality rates and increased costs. New strategies are now needed to both limit the risk of resistance and to discover new drugs that are efficacious.
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Systematic review of human gut resistome studies revealed variable definitions and approaches
Gut Microbes, 2020Peter Hawkey, Martin Chan, Xiao Yang
exaly