Results 51 to 60 of about 20,725 (257)

Cefquinome shows a higher impact on the pig gut microbiome and resistome compared to ceftiofur

Veterinary Research, 2023
Cephalosporins are licensed for treatment of severe bacterial infections in different species. However, the effect of these antimicrobials on the fecal microbiome and potential spread of resistance-associated genes causes great concern.
Sofie Rutjens, Nick Vereecke, Jannes Sauer, Siska Croubels, Mathias Devreese   +4 more
doaj   +1 more source

Comprehensive genomic landscape of antibiotic resistance in Staphylococcus epidermidis

mSystems
Staphylococcus epidermidis, a common commensal bacterium found on human skin, can cause infections in clinical settings, and the presence of antibiotic resistance genes (ARGs) impedes the treatment of S. epidermidis infections.
Do-Hoon Lee, Kihyun Lee, Yong-Seok Kim, Chang-Jun Cha   +3 more
doaj   +1 more source

The Environmental Exposures and Inner- and Intercity Traffic Flows of the Metro System May Contribute to the Skin Microbiome and Resistome [PDF]

, 2018
The skin functions as the primary interface between the human body and the external environment. To understand how the microbiome varies within urban mass transit and influences the skin microbiota, we profiled the human palm microbiome after contact ...
Archna, Anand, Baker, David Michael, Denizen, Seth, Dingle, Caroline, Heshiki, Yoshitaro, Imamovic, Lejla, Kang, Kang, Kobler, Marie Danielle, Kumari, Sarika, Li, Jun, Ni, Yueqiong, Panagiotou, Gianni, Sarkar, Chinmoy, Sommer, Morten Otto Alexander, Webster, Christopher John, Wong, Cheong Wai Martin, Wong, Jane Ching Yan, Zheng, Tingting   +17 more
core   +2 more sources

Enrichment allows identification of diverse, rare elements in metagenomic resistome-virulome sequencing

Microbiome, 2017
Background Shotgun metagenomic sequencing is increasingly utilized as a tool to evaluate ecological-level dynamics of antimicrobial resistance and virulence, in conjunction with microbiome analysis.
Noelle R. Noyes, Maggie E. Weinroth, Jennifer K. Parker, Chris J. Dean, Steven M. Lakin, Robert A. Raymond, Pablo Rovira, Enrique Doster, Zaid Abdo, Jennifer N. Martin, Kenneth L. Jones, Jaime Ruiz, Christina A. Boucher, Keith E. Belk, Paul S. Morley   +14 more
doaj   +1 more source

Discordant transmission of bacteria and viruses from mothers to babies at birth [PDF]

, 2019
BACKGROUND: The earliest microbial colonizers of the human gut can have life-long consequences for their hosts. Precisely how the neonatal gut bacterial microbiome and virome are initially populated is not well understood.
Handley, Scott A, Holtz, Lori R, Lim, Efrem S, Maqsood, Rabia, Ndao, I. Malick, Rodgers, Rachel, Rodriguez, Cynthia, Tarr, Phillip I, Warner, Barbara B   +8 more
core   +2 more sources

The Antibiotic Resistance ‘Mobilome’: searching for the link between environment and clinic.

Frontiers in Microbiology, 2013
Antibiotic resistance is an ancient problem, owing to the co-evolution of antibiotic-producing and target organisms in the soil and other environments over millennia.
Julie ePerry, Julie ePerry, Gerard eWright, Gerard eWright   +3 more
doaj   +1 more source

Perinatal risk factors for fecal antibiotic resistance gene patterns in pregnant women and their infants.

PLoS ONE, 2020
Perinatal factors can shape fecal microbiome patterns among pregnant women and their infants. However, there is scarce information about the effect of maternal demographics and perinatal exposures on antibiotic resistance genes (ARG) and mobile genetic ...
Andrea Sosa-Moreno, Sarah S Comstock, Kameron Y Sugino, Teng F Ma, Nigel Paneth, Yelena Davis, Rosemary Olivero, Rebecca Schein, Joel Maurer, Lixin Zhang   +9 more
doaj   +1 more source

Antibiotics as selectors and accelerators 1 of diversity in the mechanisms of resistance: from the resistome to genetic plasticity in the β-lactamases world [PDF]

, 2013
Antibiotics and antibiotic resistance determinants, natural molecules closely related to bacterial physiology and consistent with an ancient origin, are not only present in antibiotic-producing bacteria.
Cantón, Rafael, Galán, Juan Carlos, González Candelas, Fernando, Rolain, Jean-Marc   +3 more
core   +3 more sources

Diversity, transfer potential, and transcriptional activity of virus‐carried antibiotic resistance genes in global estuaries

iMetaOmics, EarlyView.
Estuaries are vital hotspots for antibiotic resistance genes (ARGs) due to substantial antibiotic pollution. Although viruses have been proposed as key reservoirs and important disseminators of ARGs in environments, their contribution to the estuarine antibiotic resistome remains largely unknown.
Xiao‑Qing Luo, Xiyang Dong, Jia‑Ling Li, Ji‐Cheng Yao, Ziqi Peng, Qi Li, Zi‐Wen Yang, Yang Yuan, Wen‑Jun Li, Pandeng Wang   +9 more
wiley   +1 more source

Targeting Aurora Kinases as Essential Cell‐Cycle Regulators to Deliver Multi‐Stage Antimalarials Against Plasmodium Falciparum

Angewandte Chemie, Volume 137, Issue 51, December 15, 2025.
In this study, we repurposed human Aurora kinase‐specific inhibitors to identify potential antimalarial agents. Two inhibitors, hesperadin and TAE684, exhibited sub‐micromolar activity across multiple parasite stages, with hesperadin demonstrating significant potency and selectivity by specifically targeting PfArk1.
Henrico Langeveld, Keletso Maepa, Marché Maree, Jessica L. Thibaud, Nicolaas Salomane, Rosie Bridgwater, Mufuliat T. Famodimu, Luiz C. Godoy, Charisse Flerida A. Pasaje, Nonlawat Boonyalai, Mariana Laureano de Souza, Justin Fong, Tayla Rabie, Mariëtte van der Watt, Rensu P. Theart, Sonja Ghidelli‐Disse, Jacquin C. Niles, Marcus C. S. Lee, Elizabeth A. Winzeler, Michael J. Delves, Kelly Chibale, Kathryn J. Wicht, Lauren B. Coulson, Lyn‐Marié Birkholtz   +23 more
wiley   +2 more sources