Results 151 to 160 of about 675,824 (339)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

P043 Ulcerative colitis is characterised by an exaggerated onset of acute inflammation with delayed resolution [PDF]

, 2017
Daniel JB Marks, Riccardo Wysoczanski, Alexandra C. Kendall, Madhur P. Motwani, Roser Vega, Farooq Rahman, Sara McCartney, Stuart Bloom, Anna Nicolaou, Derek W. Gilroy, Anthony W. Segal   +10 more
openalex   +1 more source

Targeting Neutrophilic Inflammation using Polymersome-Mediated Cellular Delivery [PDF]

, 2017
Neutrophils are key effector cells in inflammation and play an important role in neutralizing invading pathogens. During inflammation resolution, neutrophils undergo apoptosis before they are removed by macrophages, but if apoptosis is delayed ...
Avila-Olias, M., Battaglia, G., Renshaw, S.A., Robertson, J.D., Ward, J.R.   +4 more
core   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Targeting Neutrophil Apoptosis for Enhancing the Resolution of Inflammation

Cells, 2013
Resolution of acute inflammation is an active process that requires inhibition of further leukocyte recruitment and removal of leukocytes from inflamed sites. Emigrated neutrophils undergo apoptosis before being removed by scavenger macrophages.
Driss El Kebir, János G. Filep
doaj   +1 more source

Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation

Nature Metabolism, 2022
Satoru Sugimoto, H. A. Mena, Brian E. Sansbury, Shio Kobayashi, Tadataka Tsuji, Chih-Hao Wang, Xuanzhi Yin, Tian Lian Huang, Joji Kusuyama, S. Kodani, Justin Darcy, Gerson Profeta, Nayara Pereira, R. Tanzi, C. Zhang, T. Serwold, E. Kokkotou, L. Goodyear, A. Cypess, L. O. Leiria, Matthew Spite, Y. Tseng   +21 more
semanticscholar   +1 more source

British Society for Matrix Biology Spring 2021 Meeting: “Inflammation, Fibrosis, Resolution and the Matrix” [PDF]

, 2021
Fowkes, M. M., Vincent, T. L., Brennan, P. E., Meldal, M., Lim, N. Han   +4 more
openalex   +1 more source

Increased prevalence of precancerous changes in relatives of gastric cancer patients: critical role of H. pylori [PDF]

, 2000
Background & Aims:Helicobacter pylori is believed to predispose to gastric cancer by inducing gastric atrophy and hypochlorhydria. First-degree relatives of patients with gastric cancer have an increased risk of developing gastric cancer.
El–Nujumi, Adil, El–Omar, Emad M., Fullarton, Grant, Gillen, Derek, McColl, Kenneth E.L., Murray, Lilian S., Oien, Karin, Williams, Craig, Wirz, Angela   +8 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Impact of enriched environment on murine T cell differentiation and gene expression profile

Frontiers in Immunology, 2016
T cells are known to be plastic and to change their phenotype according to the cellular and biochemical milieu they are embedded in. In this study we transposed this concept at a macroscopic level assessing whether changes in the environmental housing ...
Lorenza Rattazzi, Giuseppa Piras, Samuel Brod, Koval Smith, Masahiro Ono, Fulvio D'Acquisto   +5 more
doaj   +1 more source