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The resolution of inflammation
Nature Reviews Immunology, 2012In 2012, Nature Reviews Immunology organized a conference that brought together scientists and clinicians from both academia and industry to discuss one of the most pressing questions in medicine--how do we turn off rampant, undesirable inflammation? There is a growing appreciation that, similarly to the initiation of inflammation, the resolution of ...
Buckley, Christopher D. +4 more
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Periodontology, 2020
Periodontitis is an infectious-inflammatory disease that results from loss of balance between the commensal microbiome and the host response. The hyper-inflammatory, uncontrolled inflammatory immune lesion promotes tissue damage and impedes effective ...
T. V. Van Dyke, C. Sima
semanticscholar +1 more source
Periodontitis is an infectious-inflammatory disease that results from loss of balance between the commensal microbiome and the host response. The hyper-inflammatory, uncontrolled inflammatory immune lesion promotes tissue damage and impedes effective ...
T. V. Van Dyke, C. Sima
semanticscholar +1 more source
DELineating resolution of inflammation
Nature Immunology, 2018The resolution of inflammation is a protective response. The identification and characterization of new players that boost this response might inform the development of novel therapies for non-resolving inflammatory diseases.
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Basic Research in Cardiology, 2014
Myocardial infarction (MI) is the main cause for the progression of the left ventricle towards congestive heart failure. The optimal healing after MI requires timely induction and resolution of inflammation. Primarily, there have been a number of strategies applied to inhibit the post-MI inflammation but approaches that focus on the resolution of ...
Vasundhara, Kain +2 more
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Myocardial infarction (MI) is the main cause for the progression of the left ventricle towards congestive heart failure. The optimal healing after MI requires timely induction and resolution of inflammation. Primarily, there have been a number of strategies applied to inhibit the post-MI inflammation but approaches that focus on the resolution of ...
Vasundhara, Kain +2 more
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1988
For centuries, the inflammatory response has been regarded as an important consequence of injury and one that normally leads to repair and restoration of function. From the battlefield observations of John Hunter in 1794 to the elegant vascular studies of Cohnheim (1889) and the descriptions of cell migration by Metchnikoff (1891) a century later, the ...
Christopher Haslett, Peter M. Henson
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For centuries, the inflammatory response has been regarded as an important consequence of injury and one that normally leads to repair and restoration of function. From the battlefield observations of John Hunter in 1794 to the elegant vascular studies of Cohnheim (1889) and the descriptions of cell migration by Metchnikoff (1891) a century later, the ...
Christopher Haslett, Peter M. Henson
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Resolution of inflammation in arthritis
Seminars in Immunopathology, 2019Rheumatoid arthritis is among the most frequent and severe chronic inflammatory diseases. The disease is characterized by ongoing synovial inflammation, which leads to the destruction of cartilage and bone. In RA, the mechanisms of resolution of inflammation, which are normally intact in the joints, are either suppressed or overruled.
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Resolution of Lung Inflammation by CD44
Science, 2002Successful repair after tissue injury and inflammation requires resolution of the inflammatory response and removal of extracellular matrix breakdown products. We have examined whether the cell-surface adhesion molecule and hyaluronan receptor CD44 plays a role in resolving lung inflammation.
Priit, Teder +7 more
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Cellular resolution of inflammation—catabasis
Wound Repair and Regeneration, 2012AbstractControlled inflammation has become a central focus in chronic disease therapeutics. Exaggerated inflammation is a common factor that contributes to matrix destruction, cellular senescence, and nonhealing in a variety of disease processes. Efforts at controlling inflammation have traditionally concentrated on systemic antagonists to inflammation
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2006
Inflammation requires clearance of the inciting pathogen, then orchestrated removal of the burden of leukocytes and other cells influxed into the inflamed site along with dissipation of the pro (or anti) inflammatory mediator cascades. We now recognize that this resolution process is strictly controlled by a number of mediators and adhesion molecules ...
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Inflammation requires clearance of the inciting pathogen, then orchestrated removal of the burden of leukocytes and other cells influxed into the inflamed site along with dissipation of the pro (or anti) inflammatory mediator cascades. We now recognize that this resolution process is strictly controlled by a number of mediators and adhesion molecules ...
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Resolution of mucosal inflammation
2008Inflammation of the mucosal lining of the gastrointestinal tract is not only common, it is often described as ‘normal’. This is particularly the case in the intestine, where a single layer of epithelial cells separates the vascular and immune systems from billions of microbes.
John L. Wallace, Philip M. Sherman
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