Results 81 to 90 of about 675,824 (339)

Lipid Mediators in Critically Ill Patients: A Step Towards Precision Medicine

Frontiers in Immunology, 2020
A dysregulated response to systemic inflammation is a common pathophysiological feature of most conditions encountered in the intensive care unit (ICU).
Luca Cioccari, Luca Cioccari, Nora Luethi, Nora Luethi, Mojgan Masoodi   +4 more
doaj   +1 more source

Acute neuroinflammation induces AIS structural plasticity in a NOX2-dependent manner [PDF]

, 2017
Background Chronic microglia-mediated inflammation and oxidative stress are well-characterized underlying factors in neurodegenerative disease, whereby reactive inflammatory microglia enhance ROS production and impact neuronal integrity. Recently, it has
Benusa, S. D., DeVries, G. H., Dupree, J. L., George, N. M., Sword, B. A.   +4 more
core   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Opposing Effects on Vascular Smooth Muscle Cell Proliferation and Macrophage-induced Inflammation Reveal a Protective Role for the Proresolving Lipid Mediator Receptor ChemR23 in Intimal Hyperplasia

Frontiers in Pharmacology, 2018
Intimal hyperplasia remains a significant clinical problem in for example coronary artery bypass graft failure. Since omega-3 fatty acids reduce intimal hyperplasia, we hypothesized that the G protein-coupled receptor ChemR23 for the omega-3-derived pro ...
Gonzalo Artiach, Miguel Carracedo, Joan Clària, Andres Laguna-Fernandez, Magnus Bäck, Magnus Bäck   +5 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Resolution of periodontal inflammation

, 2023
Diabetes affects periodontal inflammation resolution. Using ligatures to induce periodontitis in type 2 diabetic Goto-Kakizaki rats, we investigated pathways affected by inflammation in the diabetes periodontium. After 7 days, the rats were given a TNF inhibitor (pegsunercept) or a vehicle alone before being killed 4 days later.
openaire   +2 more sources

The significance of macrophage polarization subtypes for animal models of tissue fibrosis and human fibrotic diseases. [PDF]

, 2015
The systemic and organ-specific human fibrotic disorders collectively represent one of the most serious health problems world-wide causing a large proportion of the total world population mortality.
Ballater R, Beon M, Bryan N, Butterfield TA, Connolly MK, Desmoulière A, Fallowfield JA, Galván‐Peña S, Gordon S, Goumans M, Hu B, Ito T, Jimenez SA, Korns D, Krieg T, Lassen S, Lech M, Leibovich SJ, Lev B, Mantovani A, Mantovani A, Molumdar K, Nestle FO, O’Doherty U, Piera‐Velazquez S, Poland GA, Rafii R, Rigamonte E, Tacke F, Venbervliet B, Wang Y, Wick G, Wijesundera KK   +32 more
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Resolution of Cochlear Inflammation: Novel Target for Preventing or Ameliorating Drug-, Noise- and Age-related Hearing Loss

Frontiers in Cellular Neuroscience, 2017
A significant number of studies support the idea that inflammatory responses are intimately associated with drug-, noise- and age-related hearing loss (DRHL, NRHL and ARHL). Consequently, several clinical strategies aimed at reducing auditory dysfunction
Gilda M. Kalinec, Gwen Lomberk, Raul A. Urrutia, Federico Kalinec   +3 more
doaj   +1 more source

Sensory Ganglia-Specific TNF Expression Is Associated With Persistent Nociception After Resolution of Inflammation

Frontiers in Immunology, 2020
Joint pain is a distressing symptom of arthritis, and it is frequently persistent even after treatments which reduce local inflammation. Continuous production of algogenic factors activate/sensitize nociceptors in the joint structures and contribute to ...
William Antonio Gonçalves, Barbara Maximino Rezende, Marcos Paulo Esteves de Oliveira, Lucas Secchim Ribeiro, Victor Fattori, Walison Nunes da Silva, Pedro Henrique Dias Moura Prazeres, Celso Martins Queiroz-Junior, Karina Talita de Oliveira Santana, Walyson Coelho Costa, Vinícius Amorim Beltrami, Vivian Vasconcelos Costa, Alexander Birbrair, Waldiceu A. Verri, Fernando Lopes, Thiago Mattar Cunha, Mauro Martins Teixeira, Flávio Almeida Amaral, Vanessa Pinho   +18 more
doaj   +1 more source