Results 141 to 150 of about 1,075,287 (378)

Molecular determinants of signal transduction in tropomyosin receptor kinases

open access: yesFEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Dirichlet problem for second-order abstract differential equations

open access: yesElectronic Journal of Differential Equations, 2020
We study the well-posedness in the space of continuous functions of the Dirichlet boundary value problem for a homogeneous linear second-order differential equation u''+Au = 0, where A is a linear closed densely defined operator in a Banach space. We
Giovanni Dore
doaj  

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

open access: yesFEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani   +7 more
wiley   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

open access: yesFEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Asymptotic stability of fractional impulsive neutral stochastic partial integro-differential equations with state-dependent delay

open access: yesElectronic Journal of Differential Equations, 2013
In this article, we study the asymptotical stability in p-th moment of mild solutions to a class of fractional impulsive partial neutral stochastic integro-differential equations with state-dependent delay in Hilbert spaces.
Zuomao Yan, Hongwu Zhang
doaj  

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