Results 31 to 40 of about 6,147 (304)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

A proposed method to determine in-situ shear modulus and shear strain decay curves in different structured soil [PDF]

E3S Web of Conferences, 2019
This paper illustrates the application of the self-boring pressuremeter test and the seismic dilatometer test to acquire the in-situ decay curves of stiffness with shear strain level (G-γ decay curves) of three types of structural soil, which are granite
An Ran, Kong Lingwei, Guo Aiguo, Zhang Xianwei   +3 more
doaj   +1 more source

Flexural excitation in a standard torsional-resonant column device

, 1998
The excitation of specimens in multiple modes enhances the characterization of granular materials. The purpose of this paper is to present the equipment modification and test procedure and data reduction for flexural excitation in a standard torsional ...
Najwa Yassir, Carlos Santamarina, Giovanni Cascante   +2 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Measurements of Shear Wave Velocity for Collapsible Soil

Geotechnics
This paper examines the effects of collapsible soil structure on shear wave velocity. The study attempts to simulate hydraulic fill sand deposits, which represent a natural soil deposition process that can result in a collapsible soil structure. A series
Omar EI-Shafee, Inthuorn Sasanakul, Tarek Abdoun, Mourad Zeghal   +3 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Theoretical Framework for Characterizing Strain-Dependent Dynamic Soil Properties

Applied Sciences, 2019
This paper proposes a theoretical framework for the characterization of the strain-dependent dynamic properties of soils. The analysis begins with an analytical constitutive model for soils under steady-state cyclic loading.
Song-Hun Chong
doaj   +1 more source

A Parallel Comparison of Small-Strain Shear Modulus in Bender Element and Resonant Column Tests

, 2018
This paper presents an experimental study on small strain shear modulus (G0) of saturated sand specimens using both resonant column and bender element tests, with the aim to explore the impact of testing method.
Liu, X, Xin Liu, Yang, J, Jun Yang
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Strength and deformation characteristics of waste mud–solidified soil

Scientific Reports
The treatment, disposal, and resource utilization of waste mud are challenges for engineering construction. This study investigates the road performance of waste mud–solidified soil and explains how solidifying materials influence the strength and ...
Yan Tang, Han Jiang, Zide Yang, Shiyao Xiong, Gaofeng Xu, Junhao Chen, Shi Shu   +6 more
doaj   +1 more source