Results 51 to 60 of about 75,682 (299)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Seismic response of deep soft soil sites with varying shear wave velocities

Frontiers in Earth Science
The variations in seismic response between deep soft soil sites with different shear wave velocities were not fully understood. This study focuses on the seismic response of deep soft soil sites in the lower reaches of the Yangtze River, China.
Xiao-Bo Peng, Wen-Jie Ren, Tian-Qi Li, Ying-Ying Xue, Xiao-San Tao, Ling-Yu Xu   +5 more
doaj   +1 more source

A proposed method to determine in-situ shear modulus and shear strain decay curves in different structured soil [PDF]

E3S Web of Conferences, 2019
This paper illustrates the application of the self-boring pressuremeter test and the seismic dilatometer test to acquire the in-situ decay curves of stiffness with shear strain level (G-γ decay curves) of three types of structural soil, which are granite
An Ran, Kong Lingwei, Guo Aiguo, Zhang Xianwei   +3 more
doaj   +1 more source

An experimental and finite element study of the low-cycle fatigue failure of a galvanised steel lighting column [PDF]

, 2009
This paper presents the results of a low-cycle fatigue test on a lighting column. The wind induced vibration phenomena responsible for low cycle fatigue in such structures is discussed and the failure mechanism is examined.
Alexander, Louise A., Taylor, Ian, Wood, James   +2 more
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Enhanced fano resonance of organic material films deposited on arrays of asymmetric split-ring resonators (A-SRRs) [PDF]

, 2013
Depositing very thin organic films on the surface of arrays of asymmetric split-ring resonators (A-SRRs) produces a shift in their resonance spectra that can be utilized for sensitive analyte detection.
Aizpurua, Balamurugan, Basudev Lahiri, Bolivar, Brucherseifer, Cubukcu, Debus, Ding, Federici, Fedotov, Lahiri, Lahiri, Lee, Nigel P. Johnson, Nunes, Pryce, Richard M. De La Rue, Rill, Scott G. McMeekin, Soldera, Wu   +20 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Measurements of Shear Wave Velocity for Collapsible Soil

Geotechnics
This paper examines the effects of collapsible soil structure on shear wave velocity. The study attempts to simulate hydraulic fill sand deposits, which represent a natural soil deposition process that can result in a collapsible soil structure. A series
Omar EI-Shafee, Inthuorn Sasanakul, Tarek Abdoun, Mourad Zeghal   +3 more
doaj   +1 more source

Theoretical Framework for Characterizing Strain-Dependent Dynamic Soil Properties

Applied Sciences, 2019
This paper proposes a theoretical framework for the characterization of the strain-dependent dynamic properties of soils. The analysis begins with an analytical constitutive model for soils under steady-state cyclic loading.
Song-Hun Chong
doaj   +1 more source

Anomaly Detection for Resonant New Physics with Machine Learning

, 2018
Despite extensive theoretical motivation for physics beyond the Standard Model (BSM) of particle physics, searches at the Large Hadron Collider (LHC) have found no significant evidence for BSM physics.
Collins, Jack H., Howe, Kiel, Nachman, Benjamin   +2 more
core   +1 more source