Results 51 to 60 of about 6,147 (304)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers   +19 more
wiley   +1 more source

Comparison and application of small strain shear moduli from field and laboratory measurements

open access: yesYantu gongcheng xuebao, 2019
The small-strain shear modulus plays an important role in the calculations of ground seismic response and deformation in deep excavations. The values of the small strain shear modulus G0 of Shanghai soils by field and laboratory tests are investigated ...
CHEN Shao-jie 1, 2, GU Xiao-qiang 1,2, GAO Guang-yun 1, 2
doaj   +1 more source

Determination of permanent deformation of flexible pavements using finite element model

open access: yesGrađevinar, 2022
The unbound granular material used in flexible road pavements exhibits an elastoplastic behaviour under repetitive traffic loads. Permanent deformation occurring on pavement surface under traffic load is one of the main road pavement problems affecting ...
Huseyin Karadag   +3 more
doaj   +1 more source

Evaluation of ground densification using spectral analysis of surface waves (SASW) and resonant column (RC) tests

open access: yes, 1999
In order to assess the quality and depth of ground densification due to compaction, standard and (or) cone penetration tests are often performed before and after compaction.
D S Kim, H C Park
core   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro   +14 more
wiley   +1 more source

Structural damage effect on dynamic shear modulus of Zhanjiang clay and quantitative characterization

open access: yesYantu gongcheng xuebao, 2017
The Zhanjiang clay is a kind of sensitive clay with high structural strength, whose failure envelope has a significant breakpoint when the confining pressure reaches the structural yield stress.
KONG Ling-wei 1, ZANG Meng 1,2, GUO Ai-guo 1
doaj   +1 more source

Damping of Dry Sand in Resonant Column-Torsional Simple Shear Device

open access: yes, 2023
The damping ratio values of three different Danube sands were measured in the Resonant Column-Torsional Simple Shear device (RC-TOSS). The distinctive configuration of the RC-TOSS device employed in this investigation enabled the performance of both ...
Richard Ray, Majd Ahmad
core   +1 more source

Cracking the Code: Which Ocular Symptoms Predict Dry Eye Signs? Insights From a Large International Sicca Registry

open access: yesArthritis Care &Research, EarlyView.
Objective The study aimed to identify symptom‐based predictors of dry eye disease (DED) signs in the Sjögren's International Collaborative Clinical Alliance (SICCA) cohort. Methods We performed a retrospective analysis examining 16 ocular symptoms (most graded 0–4) and artificial tear (AT) use (graded 0–3) as predictors of DED signs (abnormal ocular ...
Pragnya R. Donthineni   +7 more
wiley   +1 more source

Modeling the Stiffening Behavior of Sand Subjected to Dynamic Loading

open access: yesGeosciences
In geotechnical engineering, dynamic soil models are used to predict soil behavior under different loading conditions. This is crucial for many dynamic geotechnical problems related to earthquakes, train loading and machine foundation design. Researchers
Majd Ahmad, Richard Ray
doaj   +1 more source

Drained and undrained response of fully saturated specimen in resonant column tests subjected to large number of torsional vibrations

open access: yes, 2023
In this paper, the drained and undrained responses of the saturated sand specimens have been investigated when subjected to small strain torsional excitation cycles using the resonant column apparatus.
Kumar, Jyant, Shinde, Ninad Sanjeev
core   +1 more source

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