Results 111 to 120 of about 2,704,412 (312)

Conformance analysis of land use outcomes with land use plan in Tanzania: the case of Mtanza-Msona and Mbunju-Mvuleni villages in Rufiji district

Discover Applied Sciences
Village Land Use Plans (VLUPs) are essential in guiding land users to choose land uses that meet their needs while safeguarding natural resources. However, the extent to which VLUPs have influenced actual land use outcomes remains limited.
Abdulaziz Mkwizu, Simon Mwansasu, Edmond Alavaisha   +2 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Wind and solar resource assessment and prediction using Artificial Neural Network and semi-empirical model: case study of the Colombian Caribbean region. [PDF]

Heliyon, 2021
Silvera OC, Chamorro MV, Ochoa GV.
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Economic Evaluation of Telemedicine Services Provided at Satellite Centre for Tribal Health and Research, Abu Road Sirohi Rajasthan India

Asia Pacific Journal of Health Management
Background: Assessing health technology is a vital tool for determining whether interventions should be continued or stopped. Delivering efficient medical services in remote tribal, hilly regions demands careful planning to maximize limited resources ...
Amit Kumar Mittal, Mamta Patel, Rakhi Dwivedi, Vibha Joshi, Manmohan Singh, Pradeep Dwivedi, Kuldeep Singh   +6 more
doaj  

Geospatial mapping of groundwater potential for irrigated agriculture in semi-arid Kongwa District, Central Tanzania

Frontiers in Water
Groundwater is vital for agriculture in semi-arid regions like Kongwa District, where surface water is scarce and rainfall unstable. Despite its significance, detailed knowledge on groundwater distribution in such areas is often lacking, hindering ...
Faida Zacharia, Joel Nobert, Emma Liwenga   +2 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

A Remote Laser Mass Spectrometer for Lunar Resource Assessment [PDF]

The use of lasers as a source of excitation for surface mass spectroscopy has been investigated for some time. Since the laser can be focused to a small spot with intensity, it can vaporize and accelerate atoms of material.
Deyoung, R. J., Williams, M. D.
core   +1 more source