Results 111 to 120 of about 79,637 (307)

Hierarchical Resource Management for Mega-LEO Satellite Constellation

open access: yesSensors
The mega-low Earth orbit (LEO) satellite constellation is pivotal for the future of satellite Internet and 6G networks. In the mega-LEO satellite constellation system (MLSCS), which is the spatial distribution of satellites, global users, and their ...
Liang Gou   +6 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Machine Scheduling with Resource Dependent Processing Times

open access: yes
We consider several parallel machine scheduling settings with the objective to minimize the schedule makespan. The most general of these settings is unrelated parallel machine scheduling.
Sviridenko,Maxim   +2 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

A study in grid simulation and scheduling [PDF]

open access: yes, 2006
Grid computing is emerging as an essential tool for large scale analysis and problem solving in scientific and business domains. Whilst the idea of stealing unused processor cycles is as old as the Internet, we are still far from reaching a position ...
Rhodes, Mark N.C.
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

open access: yesFEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao   +3 more
wiley   +1 more source

Risk assessment models for resource failure in grid computing [PDF]

open access: yes, 2011
Service Level Agreements (SLAs) are introduced in order to overcome the limitations associated with the best-effort approach in Grid computing, and to accordingly make Grid computing more attractive for commercial uses. However, commercial Grid providers
Alsoghayer, Raid Abdullah
core  

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

A heuristic methodology for solving spatial aresource-constrained project scheduling problems. [PDF]

open access: yes
In this paper we present a heuristic methodology for solving resource-constrained project scheduling problems with renewable and spatial resources. We especially concentrate on spatial resources that are encountered in construction projects, but our ...
Schatteman, Damien   +3 more
core  

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