Results 51 to 60 of about 902,650 (342)

Bronchial granulocytes in the development of epithelial destruction and oxidative lipid modification in patients with bronchial asthma with cold and osmotic airway hyperresponsiveness

Сибирский научный медицинский журнал, 2021
Free radical damage to the respiratory tract in patients with asthma leads to the destruction of the bronchial parenchyma and the generation of signaling molecules of inflammation by parenchymal cells.
A. B. Pirogov, A. G. Prikhodko, Ju. M. Perelman   +2 more
doaj   +1 more source

Rate-limiting Step Preceding Cytochrome c Release in Cells Primed for Fas-mediated Apoptosis Revealed by Analysis of Cellular Mosaicism of Respiratory Changes [PDF]

, 2001
In the present work, Jurkat cells undergoing anti-Fas antibody (anti-Fas)-triggered apoptosis exhibited in increasing proportion a massive release of cytochrome c from mitochondria, as revealed by double-labeling confocal immunofluorescence microscopy ...
Attardi, Giuseppe, Hájek, Petr, Villani, Gaetano   +2 more
core  

Decomposition of coarse woody debris in a long-term litter manipulation experiment: A focus on nutrient availability [PDF]

, 2018
The majority of above-ground carbon in tropical forests is stored in wood, which is returned to the atmosphere during decomposition of coarse woody debris.
Gora, Evan M., Sayer, Emma J., Tanner, Edmund V. J., Turner, Benjamin L.   +3 more
core   +3 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Interleukin-4 and interferon gamma in bronchial remodeling in asthma patients with cold airway hyperresponsiveness

Бюллетень сибирской медицины
Interleukin-4 (IL-4) and interferon gamma (IFNγ) are key participants in the polarization of the immune response toward Th1 or Th2 types in bronchial asthma.
A. B. Pirogov, A. G. Prikhodko, N. A. Pirogova, D. A. Gassan, D. E. Naumov, J. M. Perelman   +5 more
doaj   +1 more source

Destruction of the bronchial epithelium in patients with severe asthma according to different patterns of inflammation and cold airway hyperresponsiveness [PDF]

Терапевтический архив, 2019
The aim of the research was to study the state of the bronchial mucosa epi-thelium in relation to the severity of clinical manifestations in severe uncon-trolled asthma depending on the pattern of inflammation and the presence of cold airway ...
A B Pirogov, D A Gassan, S S Zinov’ev, A G Prikhodko, V P Kolosov, J M Perelman   +5 more
doaj   +1 more source

Extra-matrix Mg\u3csup\u3e2+\u3c/sup\u3e Limits Ca\u3csup\u3e2+\u3c/sup\u3e Uptake and Modulates Ca\u3csup\u3e2+\u3c/sup\u3e Uptake-independent Respiration and Redox State in Cardiac Isolated Mitochondria [PDF]

, 2013
Cardiac mitochondrial matrix (m) free Ca2+ ([Ca2+]m) increases primarily by Ca2+ uptake through the Ca2+ uniporter (CU). Ca2+ uptake via the CU is attenuated by extra-matrix (e) Mg2+ ([Mg2+]e).
Blomeyer, Christoph A., Boelens, Age D., Camara, Amadou K.S., Dash, Ranjan K., Pradhan, Ranjan K., Stowe, David F.   +5 more
core   +1 more source

Factors controlling spatio-temporal variation in carbon dioxide efflux from surface litter, roots, and soil organic matter at four rain forest sites in the eastern Amazon [PDF]

, 2007
[1] This study explored biotic and abiotic causes for spatio-temporal variation in soil respiration from surface litter, roots, and soil organic matter over one year at four rain forest sites with different vegetation structures and soil types in the ...
Aragao, L. E. O. C., Braga, A., da Costa, A. C. L., de Almeida, S. S., de Athaydes, J., Goncalves, P. H. L., Malhi, Y., Meir, P., Metcalfe, D. B., Williams, M.   +9 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Distinguish active tuberculosis with an immune-related signature and molecule subtypes: a multi-cohort analysis

Scientific Reports
Background: Distinguishing latent tuberculosis infection (LTBI) from active tuberculosis (ATB) is very important. This study aims to analyze cases from multiple cohorts and get the signature that can distinguish LTBI from ATB.
Qingqing Shan, Yangke Li, Kun Yuan, Xiao Yang, Li Yang, Jian-Qing He   +5 more
doaj   +1 more source