Results 61 to 70 of about 1,062,445 (387)

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Lymphangiomatosis with pulmonary, mediastinal, and spinal involvement in a pediatric patient: a case report

BMC Pediatrics
Background Lymphangiomatosis is a rare disorder characterized by abnormal proliferation and dilation of lymphatic vessels, resulting in non-specific clinical manifestations.
Yuxing Sun, Jun Zhou, Xiaoqin Hu, Ming Li, Li Tan   +4 more
doaj   +1 more source

Clinical Features of EGFR Double Mutation in Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2018
Background and objective The clinical features of patients with common single-mutation of epidermal growth factor receptor (EGFR) in non-small cell lung cancer (NSCLC) has been well characterized.
Mengyao WANG, Dunqiang REN, Caihong GUO, Xiaoqian DING, Hongmei WANG   +4 more
doaj   +1 more source

INTERRELATION OF CHANGES IN CONCENTRATION OF LEPTIN AND ω-3 FAMILY ACIDS IN THE PLACENTA AT THE REACTIVATION OF CYTOMEGALOVIRUS INFECTION IN THE III TRIMESTER OF HUMAN PREGNANCY

Acta Biomedica Scientifica, 2017
A gas-chromatographic study was conducted of the content of essential polyunsaturated fatty acids of the ω-3 family: eicosapentaenoic and docosahexaenoic, an enzyme-linked immunosorbent assay of leptinin the homogenate of placental tissue in women who ...
N. A. Ishutina, M. T. Lutsenko, I. A. Andrievskaya, N. N. Dorofienko   +3 more
doaj   +1 more source

On respiration [PDF]

The London, Edinburgh, and Dublin Philosophical Magazine and Journal of Science
n ...
openaire   +2 more sources

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Paper-Based Electrical Respiration Sensor.

Angewandte Chemie, 2016
Current methods of monitoring breathing require cumbersome, inconvenient, and often expensive devices; this requirement sets practical limitations on the frequency and duration of measurements.
Firat Güder, A. Ainla, Julia Redston, B. Mosadegh, B. Mosadegh, Ana C. Glavan, T. J. Martin, G. Whitesides, G. Whitesides   +8 more
semanticscholar   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Reverse Methanogenesis and Respiration in Methanotrophic Archaea

Archaea, 2017
Anaerobic oxidation of methane (AOM) is catalyzed by anaerobic methane-oxidizing archaea (ANME) via a reverse and modified methanogenesis pathway. Methanogens can also reverse the methanogenesis pathway to oxidize methane, but only during net methane ...
P. Timmers, C. Welte, J. Koehorst, C. Plugge, M. Jetten, A. Stams   +5 more
semanticscholar   +1 more source