Results 11 to 20 of about 497,443 (308)

The Enigma of the Respiratory Chain Supercomplex [PDF]

Cell Metabolism, 2017
Respiratory chain dysfunction plays an important role in human disease and aging. It is now well established that the individual respiratory complexes can be organized into supercomplexes, and structures for these macromolecular assemblies, determined by electron cryo-microscopy, have been described recently. Nevertheless, the reason why supercomplexes
Milenkovic, D, Blaza, JN, Larsson, N-G, Hirst, J   +3 more
openaire   +5 more sources

Supersizing the Mitochondrial Respiratory Chain [PDF]

Cell Metabolism, 2012
The complexes of the mitochondrial respiratory chain assemble into higher-order structures called supercomplexes or respirasomes that are thought to be important in channeling electron flow and controlling ROS production. A number of recent papers identify the first protein factors necessary for supercomplex assembly and stability.
Shoubridge, Eric A.
openaire   +3 more sources

Arrangement of electron transport chain components in bovine mitochondrial supercomplex I1III2IV1 [PDF]

, 2011
The respiratory chain in the inner mitochondrial membrane contains three large multi-enzyme complexes that together establish the proton gradient for ATP synthesis, and assemble into a supercomplex.
Mills, Deryck J., Althoff, Thorsten, Werner Kühlbrandt, Althoff, T., Popot, Jean-Luc, Mills, D. ; https://orcid.org/, Kühlbrandt, W. ; https://orcid.org/, Thorsten Althoff, Deryck J Mills, Kühlbrandt, Werner, Jean-Luc Popot, Popot, J.   +11 more
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The mitochondrial respiratory complex I is a target for 15-deoxy-Δ12,14-prostaglandin J2 action

Journal of Lipid Research, 2005
The prostaglandin J2 derivative 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) is a very active compound with important effects on inflammation, apoptosis, and cell growth processes.
B. Martínez, A. Pérez-Castillo, A. Santos   +2 more
doaj   +1 more source

Genetics, recombination and clinical features of human rhinovirus species C (HRV-C) infections; interactions of HRV-C with other respiratory viruses [PDF]

, 2009
To estimate the frequency, molecular epidemiological and clinical associations of infection with the newly described species C variants of human rhinoviruses (HRV), 3243 diagnostic respiratory samples referred for diagnostic testing in Edinburgh were ...
Anne Wisdom, Gaunt, Eleanor R, Gaunt, E., Harvala, H., McWilliam Leitch, E.C., Aldona E Kutkowska, E Carol McWilliam Leitch, Kate Templeton, Kutkowska, A.E., Templeton, K., Peter Simmonds, Wisdom, A., Heli Harvala, Simmonds, P., Eleanor Gaunt   +14 more
core   +1 more source

Mitochondrial respiratory chain dysfunction alters ER sterol sensing and mevalonate pathway activity

, 2022
Mitochondrial dysfunction induces a strong adaptive retrograde signaling response; however, many of the downstream effectors of this response remain to be discovered.
Descombes, Patrick, Wiederkehr, Andreas, Lefebvre, Gregory, Santo-Domingo, Jaime, Metairon, Sylviane, Wall, Christopher Tadhg James   +5 more
core   +1 more source

Impairment of respiratory chain under nutrient deficiencies in plants: does it play a role in the regulation of iron and sulfur responsive genes?

Frontiers in Plant Science, 2016
Plant production and plant product quality strongly depends on the availability of mineral nutrients. Among them, sulfur (S) and iron (Fe) play a central role, as they are needed for many proteins of the respiratory chain.
GIANPIERO eVIGANI, Jean François eBRIAT
doaj   +1 more source

A Proteomic Analysis Indicates That Oxidative Stress Is the Common Feature Triggering Antibiotic Production in Streptomyces coelicolor and in the pptA Mutant of Streptomyces lividans

Frontiers in Microbiology, 2022
In most Streptomyces species, antibiotic production is triggered in phosphate limitation and repressed in phosphate proficiency. However, the model strain, Streptomyces coelicolor, escapes this general rule and produces actinorhoddin (ACT), a polyketide ...
Clara Lejeune, Laila Sago, David Cornu, Virginie Redeker, Virginie Redeker, Marie-Joelle Virolle   +5 more
doaj   +1 more source

Phenotypic effects of dietary stress in combination with a respiratory chain bypass in mice

Physiological Reports, 2019
The alternative oxidase (AOX) from Ciona intestinalis was previously shown to be expressible in mice and to cause no physiological disturbance under unstressed conditions.
Praveen K. Dhandapani, Annina M. Lyyski, Lars Paulin, Nahid A. Khan, Anu Suomalainen, Petri Auvinen, Eric Dufour, Marten Szibor, Howard T. Jacobs   +8 more
doaj   +1 more source

Natural Mitochondria Targeting Substances and Their Effect on Cellular Antioxidant System as a Potential Benefit in Mitochondrial Medicine for Prevention and Remediation of Mitochondrial Dysfunctions

Current Issues in Molecular Biology, 2023
Based on the knowledge that many diseases are caused by defects in the metabolism of the cells and, in particular, in defects of the mitochondria, mitochondrial medicine starts precisely at this point.
Daniel Schniertshauer, Susanne Wespel, Jörg Bergemann   +2 more
doaj   +1 more source