Results 1 to 10 of about 471,794 (163)

Respiratory chain gene mutations associated with global phylogenetic clustering of drug-resistant Mycobacterium tuberculosis revealed by whole-genome sequencing [PDF]

Frontiers in Immunology
BackgroundThe regulatory mechanism of respiratory chain in Mycobacterium tuberculosis (M. tuberculosis) remains to be elucidated, and limited evidence about the effect of gene mutations in the respiratory chain on multidrug-resistant (MDR) isolates was ...
Qiang Ji, Yawei Hou, Yameng Li
doaj   +2 more sources

Epigenetic regulation of the respiratory chain by a mitochondrial distress-related redox signal [PDF]

Frontiers in Cell and Developmental Biology
Different signaling pathways connect the mitochondrion with the transcriptional machinery in the nucleus. Redox events are thought to play a substantial role along this axis, however, many open questions about their specificity and mode of action remain.
Marius W. Baeken, Marius W. Baeken, Ankush Borlepawar, Philipp Kötzner, Holger Richly, Christian Behl, Bernd Moosmann, Parvana Hajieva, Parvana Hajieva   +8 more
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The functional significance of mitochondrial respiratory chain supercomplexes [PDF]

EMBO Reports, 2023
Andreas Aufschnaiter, Antoni Barrientos, Flavia Fontanesi   +2 more
exaly   +2 more sources

Oxidative Phosphorylation for Aerobic Survival, but Not for Growth: The Peculiar ‘Make-Accumulate-Consume’ Strategy in Zymomonas mobilis

Fermentation, 2023
Understanding the energy metabolism and its regulation is one of the clues to metabolic engineering of stress-resistant lignocellulose-converting microbial strains, also including the promising ethanologen Zymomonas mobilis. Z.
Inese Strazdina, Mara Bikerniece, Evelina Rezija Paegle, Karlis Shvirksts, Mara Grube, Zane Lasa, Reinis Rutkis, Uldis Kalnenieks   +7 more
doaj   +1 more source

Relevance of NADH Dehydrogenase and Alternative Two-Enzyme Systems for Growth of Corynebacterium glutamicum With Glucose, Lactate, and Acetate

Frontiers in Bioengineering and Biotechnology, 2021
The oxidation of NADH with the concomitant reduction of a quinone is a crucial step in the metabolism of respiring cells. In this study, we analyzed the relevance of three different NADH oxidation systems in the actinobacterial model organism ...
Tomoya Maeda, Abigail Koch-Koerfges, Michael Bott   +2 more
doaj   +1 more source

Insulin-Degrading Enzyme Interacts with Mitochondrial Ribosomes and Respiratory Chain Proteins

Biomolecules, 2023
Insulin-degrading enzyme (IDE) is a highly conserved metalloprotease that is mainly localized in the cytosol. Although IDE can degrade insulin and some other low molecular weight substrates efficiently, its ubiquitous expression suggests additional ...
Ayse Yilmaz, Chiara Guerrera, Emmanuelle Waeckel-Énée, Joanna Lipecka, Barbara Bertocci, Peter van Endert   +5 more
doaj   +1 more source

Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation

eLife, 2021
Respiratory complex I is a multi-subunit membrane protein complex that reversibly couples NADH oxidation and ubiquinone reduction with proton translocation against transmembrane potential.
Piotr Kolata, Rouslan G Efremov
doaj   +1 more source

MELAS with multiple stroke‐like episodes due to the variant m.13513G>A in MT‐ND5

Clinical Case Reports, 2022
Mitochondrial encephalopathy, lactic acidosis, and stroke‐like episodes (MELAS) is characterized by metabolic stroke, seizures, cognitive decline, lactic acidosis, ragged‐red fibers, headache, and vomiting, and in 80% of cases due to the mtDNA variant m ...
Ritwik Ghosh, Souvik Dubey, Subhas Bhuin, Durjoy Lahiri, Biman Kanti Ray, Josef Finsterer   +5 more
doaj   +1 more source

SUMOylation Modulates Reactive Oxygen Species (ROS) Levels and Acts as a Protective Mechanism in the Type 2 Model of Diabetic Peripheral Neuropathy

Cells, 2023
Diabetic peripheral neuropathy (DPN) is the prevalent type of peripheral neuropathy; it primarily impacts extremity nerves. Its multifaceted nature makes the molecular mechanisms of diabetic neuropathy intricate and incompletely elucidated. Several types
Nicolas Mandel, Michael Büttner, Gernot Poschet, Rohini Kuner, Nitin Agarwal   +4 more
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Effect of dietary lysine on performance and expression of electron transport chain genes in the pectoralis major muscle of broilers

Animal, 2017
The aim of this study was to evaluate the effect of dietary lysine on performance, protein deposition and respiratory chain gene expression in male broilers.
C.O. Brito, J.L.L. Dutra, T.N. Dias, L.T. Barbosa, C.S. Nascimento, A.P.G. Pinto, L.F.T. Albino, R.P.M. Fernandes, M.S. Macário, J.S. Melo   +9 more
doaj   +1 more source