Results 41 to 50 of about 496,340 (170)

Exploring membrane respiratory chains

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2016
Acquisition of energy is central to life. In addition to the synthesis of ATP, organisms need energy for the establishment and maintenance of a transmembrane difference in electrochemical potential, in order to import and export metabolites or to their motility. The membrane potential is established by a variety of membrane bound respiratory complexes.
Bruno C. Marreiros, Filipa Calisto, Paulo J. Castro, Afonso M. Duarte, Filipa V. Sena, Andreia F. Silva, Filipe M. Sousa, Miguel Teixeira, Patrícia N. Refojo, Manuela M. Pereira   +9 more
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Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Alternative oxidase‐mediated respiration prevents lethal mitochondrial cardiomyopathy

EMBO Molecular Medicine, 2018
Alternative oxidase (AOX) is a non‐mammalian enzyme that can bypass blockade of the complex III‐IV segment of the respiratory chain (RC). We crossed a Ciona intestinalis AOX transgene into RC complex III (cIII)‐deficient Bcs1lp.S78G knock‐in mice ...
Jayasimman Rajendran, Janne Purhonen, Saara Tegelberg, Olli‐Pekka Smolander, Matthias Mörgelin, Jan Rozman, Valerie Gailus‐Durner, Helmut Fuchs, Martin Hrabe de Angelis, Petri Auvinen, Eero Mervaala, Howard T Jacobs, Marten Szibor, Vineta Fellman, Jukka Kallijärvi   +14 more
doaj   +1 more source

Metabolic control analysis of respiration in human cancer tissue

Frontiers in Physiology, 2013
Bioenergetic profiling of cancer cells is of great potential because it can bring forward new and effective therapeutic strategies along with early diagnosis.
Tuuli eKaambre, Vladimir eChekulayev, Igor eShevchuk, Kersti eTepp, Natalja eTimohhina, Minna eVarikmaa, Rafaela eBagur, Aleksandr eKlepinin, Tiia eAnmann, Andre eKoit, Andrus eKaldma, Rita eGuzun, Vahur eValvere, Vahur eValvere, Valdur eSaks, Valdur eSaks   +15 more
doaj   +1 more source

The Enigma of the Respiratory Chain Supercomplex [PDF]

Cell Metabolism, 2017
Respiratory chain dysfunction plays an important role in human disease and aging. It is now well established that the individual respiratory complexes can be organized into supercomplexes, and structures for these macromolecular assemblies, determined by electron cryo-microscopy, have been described recently. Nevertheless, the reason why supercomplexes
Milenkovic, D, Blaza, JN, Larsson, N-G, Hirst, J   +3 more
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The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Metabolic Engineering of Bacterial Respiration: High vs. Low P/O and the Case of Zymomonas mobilis

Frontiers in Bioengineering and Biotechnology, 2019
Respiratory chain plays a pivotal role in the energy and redox balance of aerobic bacteria. By engineering respiration, it is possible to alter the efficiency of energy generation and intracellular redox state, and thus affect the key bioprocess ...
Uldis Kalnenieks, Elina Balodite, Reinis Rutkis   +2 more
doaj   +1 more source

Transcriptome Analysis Revealed That Hydrogen Peroxide-Regulated Oxidative Phosphorylation Plays an Important Role in the Formation of Pleurotus ostreatus Cap Color

Journal of Fungi, 2023
Pleurotus ostreatus is widely cultivated in China. H2O2, as a signaling molecule, can regulate the formation of cap color, but its regulatory pathway is still unclear, severely inhibiting the breeding of dark-colored strains.
Ludan Hou, Kexing Yan, Shuai Dong, Lifeng Guo, Jingyu Liu, Shurong Wang, Mingchang Chang, Junlong Meng   +7 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Supersizing the Mitochondrial Respiratory Chain [PDF]

Cell Metabolism, 2012
The complexes of the mitochondrial respiratory chain assemble into higher-order structures called supercomplexes or respirasomes that are thought to be important in channeling electron flow and controlling ROS production. A number of recent papers identify the first protein factors necessary for supercomplex assembly and stability.
openaire   +2 more sources