Results 31 to 40 of about 1,332,050 (100)

Overexpression of STX11 alleviates pulmonary fibrosis by inhibiting fibroblast activation via the PI3K/AKT/mTOR pathway

Signal Transduction and Targeted Therapy
Fibroblast activation plays an important role in the occurrence and development of idiopathic pulmonary fibrosis (IPF), which is a progressive, incurable, and fibrotic lung disease.
Guichuan Huang, Xiangsheng Yang, Qingyang Yu, Qun Luo, Chunrong Ju, Bangyan Zhang, Yijing Chen, Zihan Liang, Shu Xia, Xiaohua Wang, Dong Xiang, Nanshan Zhong, Xiao Xiao Tang   +12 more
doaj   +1 more source

Idiopathic pleuroparenchymal fibroelastosis in a patient with pectus excavatum: an overlooked association

Asian Journal of Internal Medicine
Pleuroparenchymal fibroelastosis (PPFE) is a rare, progressive interstitial lung disease characterised by prominent upper lobe fibrosis and elastotic changes. Its aetiology remains unclear, with most cases classified as idiopathic.
K. Maduranga, A. P. D. Manodhya, S. Palihawadene, E. Perara   +3 more
doaj   +1 more source

One-step diagnosis of infection and lung cancer using metagenomic sequencing

Respiratory Research
Background Traditional detection methods face challenges in meeting the diverse clinical needs for diagnosing both lung cancer and infections within a single test. Onco-mNGS has emerged as a promising solution capable of accurately identifying infectious
Shaoqiang Li, Yangqing Zhan, Yan Wang, Weilong Li, Xidong Wang, Haoru Wang, Wenjun Sun, Xuefang Cao, Zhengtu Li, Feng Ye   +9 more
doaj   +1 more source

Airway Organoid Models as Pivotal Tools for Unraveling Molecular Mechanisms and Therapeutic Targets in Respiratory Diseases: A Literature Review

Therapeutics and Clinical Risk Management
Shu-Ping Jiang,1,* Bing-Qi Lin,1,* Xing-Qiang Zhou,2,* Min-Hua Li,1,* Zhen-Cheng Feng,1 Yue-Ying Qin,1 Shi-Qi Lin,1 Zi-Qing Zhou,1 Yang Peng,1 Lian Li1 1State Key Laboratory of Respiratory Disease, National Clinical ...
Jiang SP, Lin BQ, Zhou XQ, Li MH, Feng ZC, Qin YY, Lin SQ, Zhou ZQ, Peng Y, Li L   +9 more
doaj  

Phenotypic heterogeneity in mortality and prognosis of pulmonary alveolar proteinosis: a large-scale, global pooled analysis of individual-level data

Orphanet Journal of Rare Diseases
Background Pulmonary Alveolar Proteinosis (PAP) is a rare interstitial lung disease with diverse clinical manifestations and outcomes. However, there are limited data on the heterogeneity of PAP, as well as its prognosis, cause of death and genetic ...
Junfeng Huang, Shuojia Xie, Yuewen Gao, Zikai Lin, Zhe Xu, Jinsheng Lin, Linzhi He, Gengjia Chen, Ziwen Zheng, Zhixing Xu, Jingyan Chen, Jiaming Guo, Zhile Wu, Ailing Duan, Weizhan Luo, Xinyu Song, Shiyue Li   +16 more
doaj   +1 more source

Efficacy and safety of tetramethylpyrazine phosphate on pulmonary hypertension: study protocol for a randomized controlled study

Trials, 2019
Background Tetramethylpyrazine (TMP), an active ingredient in the traditional Chinese herbal medicine Rhizoma Chuanxiong, has been used clinically for the prevention and treatment of cardiovascular disease.
Yuqin Chen, Wenjun He, Haiping Ouyang, Chunli Liu, Cheng Hong, Tao Wang, Kai Yang, Wenju Lu, Jian Wang   +8 more
doaj   +1 more source

Antibody dynamics for heterologous boosters with aerosolized Ad5-nCoV following inactivated COVID-19 vaccines

Human Vaccines & Immunotherapeutics
The COVID-19 pandemic has underscored vaccination as a crucial strategy for reducing disease severity and preventing hospitalizations. Heterologous boosters using aerosolized Ad5-nCoV following two doses of inactivated vaccine have demonstrated superior ...
Canjie Chen, Tian Tang, Zhao Chen, Lan Chen, Jinling Cheng, Fang Li, Jing Sun, Jingxian Zhao, Yanqun Wang, Qihong Yan, Jincun Zhao, Airu Zhu   +11 more
doaj   +1 more source

Inhalation of hydrogen gas protects against mitomycin-induced pulmonary veno-occlusive disease

Respiratory Research
Background As a subtype of pulmonary hypertension (PH), pulmonary veno-occlusive disease (PVOD) is devastating and life-threatening disease without effective therapy.
Chenting Zhang, Yue Xing, Xuefen Wu, Qian Jiang, Xiaoyun Luo, Wei He, Shiyun Liu, Wenju Lu, Jian Wang   +8 more
doaj   +1 more source

Global, regional, and national burden of chronic obstructive pulmonary disease and its attributable risk factors from 1990 to 2021: an analysis for the Global Burden of Disease Study 2021

Respiratory Research
Background Chronic obstructive pulmonary disease (COPD) continues to be a significant issue, leading to premature death or reduced quality of life. It’s important to assess the current burden of COPD and its risk factors on a geographical basis to guide ...
Zhufeng Wang, Junfeng Lin, Lina Liang, Feifei Huang, Xiaoyin Yao, Kang Peng, Yi Gao, Jinping Zheng   +7 more
doaj   +1 more source

Prone position ventilation-induced oxygenation improvement as a valuable predictor of survival in patients with acute respiratory distress syndrome: a retrospective observational study

BMC Pulmonary Medicine
Background In patients with severe acute respiratory distress syndrome (ARDS), prolonged and inappropriate use of prone position ventilation (PPV) is a known risk factor for mortality.
Hanwen Liang, Qiuxue Deng, Weiyan Ye, Zhenjie Jiang, Baozhu Zhang, Jiesen Zhang, Mei Jiang, Yuanda Xu   +7 more
doaj   +1 more source