Results 61 to 70 of about 1,079,519 (296)

Nicotine replacement therapy as a smoking cessation tool for adolescents: an update

Frontiers in Psychiatry
BackgroundAdolescent smoking is a significant public health concern, as early nicotine addiction leads to more severe addiction and reduced cessation success during adulthood.
Ioannis Beis, Anastasios Dimou, Serafeim-Chrysovalantis Kotoulas, Athanasia Pataka   +3 more
doaj   +1 more source

What role does the right side of the heart play in circulation? [PDF]

, 2006
Right ventricular failure (RVF) is an underestimated problem in intensive care. This review explores the physiology and pathophysiology of right ventricular function and the pulmonary circulation.
Cecconi, M, Johnston, E, Rhodes, A
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Endothelial biomarkers (Von willebrand factor, BDCA3, urokinase) as predictors of mortality in COVID-19 patients: cohort study

BMC Pulmonary Medicine
Background SARS-CoV-2 is a systemic disease that affects endothelial function and leads to coagulation disorders, increasing the risk of mortality.
Rocío Nayeli Sánchez-Santillán, Martha Patricia Sierra-Vargas, Dulce González-Islas, Octavio Gamaliel Aztatzi-Aguilar, Rogelio Pérez-Padilla, Arturo Orea-Tejeda, Yazmín Debray-García, Manolo Ortega-Romero, Candace Keirns-Davis, Alejandra Loaeza-Roman, Alejandra Rios-Pereda   +10 more
doaj   +1 more source

Personalised pulmonary rehabilitation in COPD

European Respiratory Review, 2018
This review summarises ongoing developments in personalised medicine and individualised medicine in chronic obstructive pulmonary disease (COPD). Currently applied classification systems largely ignore the complexity and heterogeneity of the COPD ...
Emiel F.M. Wouters, Birgit B.R.E.F. Wouters, Ingrid M.L. Augustin, Sarah Houben-Wilke, Lowie E.G.W. Vanfleteren, Frits M.E. Franssen   +5 more
doaj   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Principles of Inhalation Therapy [PDF]

, 1973
With the increasing complexity of ventilatory equipment and the rapid development of new techniques for respiratory care, it has become progressively more difficult for the average physician to keep pace with clinical and technical advancements.
O\u27Donohue, Walter J., Jr.
core   +1 more source

Rituximab induced pulmonary edema managed with extracorporeal life support [PDF]

, 2018
Though rare, rituximab has been reported to induce severe pulmonary edema. We describe the first report of ECLS utilization for this indication. A 31-year-old female with severe thrombotic thrombocytopenic purpura developed florid pulmonary edema after ...
Aguilar, Patrick, Balsara, Keki R, Isakow, Warren, Itoh, Akinobu, Masood, Muhammad F, Miller, Jacob R, Sanfilippo, Kristen M   +6 more
core   +3 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

The Lung Microbiome and Its Impact on Obstructive Sleep Apnea: A Diagnostic Frontier

Diagnostics
Obstructive sleep apnea (OSA), a prevalent disorder characterized by recurrent upper airway collapse, is increasingly recognized as a systemic inflammatory condition influenced by microbial dysregulation. Emerging evidence underscores the lung microbiome
Aliki Karkala, Serafeim-Chrysovalantis Kotoulas, Asterios Tzinas, Eleni Massa, Eleni Mouloudi, Foteini Gkakou, Athanasia Pataka   +6 more
doaj   +1 more source