Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Effect of inspiratory pressure support on exercise performance in patients with chronic obstructive pulmonary disease [PDF]
, 2006 Title: Effect of inspiratory pressure support on exercise performance in patients with chronic obstructive pulmonary disease. Purpose: This study examined the effects of a non-invasive ventilator on submaximal and maximal exercise performance in ...
Doggett, Anita
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Bronchiolitis obliterans. [PDF]
, 1989 Bronchiolitis obliterans in the adult patient is a relatively uncommon and vexing clinical entity. This confusion results because this pathologic finding occurs in a variety of diverse clinical settings.
King, TE
core
High cycling cadence reduces carbohydrate oxidation at given low intensity metabolic rate [PDF]
, 2014 Cycling cadence (RPM)-related differences in blood lactate concentration (BLC) increase with increasing exercise intensity, whilst corresponding divergences in oxygen uptake (VO2) and carbon dioxde production (VCO2) decrease.
Alkhatib, Ahmad, Beneke, Ralph
core +6 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Effect of Preventive Supplementation with Zinc and other Micronutrients on Non-Malarial Morbidity in Tanzanian Pre-School Children: A Randomized Trial. [PDF]
, 2012 The efficacy of preventive zinc supplementation against diarrhea and respiratory illness may depend on simultaneous supplementation with other micronutrients.
Ayşe Y. Demir +10 more
core +13 more sources
Pulmonary Function Tests and Work-Related Respiratory and Allergic
Iranian Journal of Allergy, Asthma and Immunology, 2009 Bakers are frequently exposed to various irritant chemicals during work which can induce respiratory problems. In this study, pulmonary function tests and self-reported respiratory and allergic symptoms in bakers were compared with matched control ...
Boskabady Mohammad Hosein +6 more
doaj
OSCILOMETRIA DE IMPULSO E ESPIROMETRIA EM ESCOLARES SUBMETIDOS AO TESTE DE CAMINHADA DE SEIS MINUTOS
Revista Paulista de Pediatria, 2018 RESUMO Objetivo: Verificar as repercussões do teste de esforço submáximo na mecânica respiratória e na função pulmonar de escolares. Métodos: Estudo transversal com escolares de 7 a 14 anos submetidos à avaliação da mecânica respiratória por sistema ...
Maíra Seabra de Assumpção +4 more
doaj +1 more source
European Respiratory Society International Congress best abstract preview from the allied respiratory professionals from assembly 9 [PDF]
, 2018 The 28th European Respiratory Society (ERS) International Congress [2018] in Paris features interesting research findings within the allied respiratory professional assembly (assembly 9).
Blonshine, Jason +3 more
core +1 more source