Results 1 to 10 of about 1,301,761 (208)

Intermittent hypercapnic hypoxia induces respiratory hypersensitivity to fentanyl accompanied by tonic respiratory depression by endogenous opioids. [PDF]

J Physiol, 2020
Sleep apnoea increases susceptibility to opioid‐induced respiratory depression (OIRD). Endogenous opioids are implicated as a contributing factor in sleep apnoea.
Brackley AD, Andrade MA, Toney GM.
europepmc   +4 more sources

Evaluation of a translational swine model of respiratory hypersensitivity induced by exposure to Phleum pratense pollen allergens [PDF]

Frontiers in Allergy
IntroductionAsthma is a disease characterized by chronic inflammation of the airway mucosa that causes tissue remodeling and a reversible decrease in airflow.
Jessica Ledesma-Aparicio, Gustavo Salazar-Guerrero, Axel Soto-Muñoz, Carmen Ramírez-Estudillo, Mónica Luz Gómez-Esquivel, Juan Pablo Reyes-Grajeda, César A. Reyes-López, Marco A. Vega-López   +7 more
doaj   +4 more sources

Respiratory hypersensitivity reaction related to ingestion of raspberry [PDF]

Journal of Cutaneous Immunology and Allergy, 2023
A 27‐year‐old woman developed dyspnea and wheezing within 10 min after eating a piece of raspberry walnut cake, and was successfully treated with intravenous corticosteroid and intramuscular injection of adrenaline.
Yuki Akamatsu, Yoshio Kawakami, Shusaku Fujita, Tomoko Kawamoto, Tomoko Miyake, Yoji Hirai, Shin Morizane   +6 more
doaj   +3 more sources

Assessing the Potential to Induce Respiratory Hypersensitivity [PDF]

Toxicological Sciences, 2005
Acute and repeat dose inhalation studies have been an important part of the safety assessment of drugs, chemicals, and other products throughout the world for many years. It is known that damage to the respiratory tract can be triggered either by nonspecific irritation or by specific immune-mediated pathogenesis, and it is acknowledged that traditional
Holsapple, Michael P., Jones, David, Kawabata, Thomas T., Kimber, Ian, Sarlo, Kathy, Selgrade, Mary Jane K, Shah, Jui, Woolhiser, Michael R.   +7 more
openaire   +3 more sources

Hypersensitivity in the lungs is responsible for acute respiratory failure in COVID‐19 patients: Case series of patients who received high‐dose/short‐term methylprednisolone

Clinical and Translational Allergy, 2021
Background COVID‐19 is a highly contagious respiratory disease caused by the SARS‐CoV‐2 virus. Patients with severe disease have a high fatality rate and face a huge medical burden due to the need for invasive mechanical ventilation.
Meizhu Chen, Changli Tu, Cuiyan Tan, Xiaobin Zheng, Fengfei Sun, Yingjian Liang, Honglei Shi, Jian Wu, Yiying Huang, Zhenguo Wang, Kongqiu Wang, Minmin Lin, Weiming Wu, Hong Zhou, Jing Liu, Jin Huang   +15 more
doaj   +2 more sources

Long-term nitric oxide exposure induces cough hypersensitivity via non-inflammatory activation of the HIF1α–TRPV1 pathway [PDF]

Frontiers in Pharmacology
BackgroundChronic cough hypersensitivity is common across respiratory diseases and often occurs without airway inflammation, yet effective treatments remain limited.
Jingxin Zhao, Jinjun Jiang, Peifang Zhang, Yue Xiong, Rong Yan, Chuling Zhang, Xuan Zeng, Wenbin Deng, Yichu Nie, Yichu Nie   +9 more
doaj   +2 more sources

Omalizumab for Aspirin Hypersensitivity and Leukotriene Overproduction in Aspirin-exacerbated Respiratory Disease. A Randomized Controlled Trial

American Journal of Respiratory and Critical Care Medicine, 2020
Rationale: Aspirin-exacerbated respiratory disease is characterized by severe asthma, nonsteroidal antiinflammatory drug hypersensitivity, nasal polyposis, and leukotriene overproduction.
H. Hayashi, Y. Fukutomi, C. Mitsui, K. Kajiwara, K. Watai, Y. Kamide, Y. Nakamura, Y. Hamada, Y. Tomita, K. Sekiya, T. Tsuburai, K. Izuhara, K. Wakahara, N. Hashimoto, Y. Hasegawa, M. Taniguchi   +15 more
semanticscholar   +2 more sources

The Respiratory Microbiome in Chronic Hypersensitivity Pneumonitis Is Distinct from That of Idiopathic Pulmonary Fibrosis

American Journal of Respiratory and Critical Care Medicine, 2020
Rationale: Chronic hypersensitivity pneumonitis (CHP) is a condition that arises after repeated exposure and sensitization to inhaled antigens. The lung microbiome is increasingly implicated in respiratory disease, but, to date, no study has investigated
R. Invernizzi, Benjamin G. Wu, J. Barnett, P. Ghai, S. Kingston, R. Hewitt, Johanna Feary, Yonghua Li, F. Chua, Zhe Wu, A. Wells, E. Renzoni, A. Nicholson, A. Rice, A. Devaraj, L. Segal, A. Byrne, T. Maher, C. Lloyd, P. Molyneaux   +19 more
semanticscholar   +2 more sources

Chemical respiratory sensitization—Current status of mechanistic understanding, knowledge gaps and possible identification methods of sensitizers

Frontiers in Toxicology
Respiratory sensitization is a complex immunological process eventually leading to hypersensitivity following re-exposure to the chemical. A frequent consequence is occupational asthma, which may occur after long latency periods.
Rita Hargitai, Lucia Parráková, Tünde Szatmári, Pablo Monfort-Lanzas, Pablo Monfort-Lanzas, Valentina Galbiati, Karine Audouze, Florence Jornod, Yvonne C. M. Staal, Sabina Burla, Aline Chary, Arno C. Gutleb, Katalin Lumniczky, Rob J. Vandebriel, Johanna M. Gostner   +14 more
doaj   +2 more sources

Cross-reactivity between halogenated platinum salts in an immediate-type respiratory hypersensitivity model. [PDF]

Inhal Toxicol, 2018
Lehmann DM, Williams WC.
europepmc   +3 more sources