Results 21 to 30 of about 1,462,578 (219)

Hypersensitivity Reactions to Nonsteroidal Anti-Inflammatory Drugs: An Update

Pharmaceuticals, 2010
After beta lactam antibiotics, hypersensitivity reactions to nonsteroidal antiinflammatory drugs are the second cause of hypersensitivity to drugs. Acute manifestations affect the respiratory tract (aspirin exacerbated respiratory disease), the skin ...
Luis González-Aveledo, Arnaldo Capriles-Hulett, Fernan Caballero-Fonseca, Mario Sánchez-Borges   +3 more
doaj   +2 more sources

Chemical respiratory sensitization—Current status of mechanistic understanding, knowledge gaps and possible identification methods of sensitizers

Frontiers in Toxicology
Respiratory sensitization is a complex immunological process eventually leading to hypersensitivity following re-exposure to the chemical. A frequent consequence is occupational asthma, which may occur after long latency periods.
Rita Hargitai, Lucia Parráková, Tünde Szatmári, Pablo Monfort-Lanzas, Pablo Monfort-Lanzas, Valentina Galbiati, Karine Audouze, Florence Jornod, Yvonne C. M. Staal, Sabina Burla, Aline Chary, Arno C. Gutleb, Katalin Lumniczky, Rob J. Vandebriel, Johanna M. Gostner   +14 more
doaj   +2 more sources

Long-term nitric oxide exposure induces cough hypersensitivity via non-inflammatory activation of the HIF1α–TRPV1 pathway [PDF]

Frontiers in Pharmacology
BackgroundChronic cough hypersensitivity is common across respiratory diseases and often occurs without airway inflammation, yet effective treatments remain limited.
Jingxin Zhao, Jinjun Jiang, Peifang Zhang, Yue Xiong, Rong Yan, Chuling Zhang, Xuan Zeng, Wenbin Deng, Yichu Nie, Yichu Nie   +9 more
doaj   +2 more sources

364 The positive allosteric modulator BMS-122 increases the efficacy of opioid and non-opioid analgesics neuropathic pain [PDF]

Journal of Clinical and Translational Science
Objectives/Goals: Opioids treat pain but with the risk of severe adverse effects. The opioid positive allosteric modulator BMS-122 has been shown to enhance opioid antinociception in animal models without increasing adverse effects.
Benjamin Clements, Katherine E. Kerrigan, Che Hsuing-Lee, Ipek Berberoglu, Stephen W.P. Kemp, John R. Traynor   +5 more
doaj   +2 more sources

Cross-reactivity between halogenated platinum salts in an immediate-type respiratory hypersensitivity model [PDF]

Inhalation Toxicology, 2018
David M Lehmann
exaly   +2 more sources

Phenytoin-induced acute hypersensitivity pneumonitis

Lung India, 2015
Lungs are target organs for toxic effects of various drugs due to many reasons. Diphenylhydantoin (DPH) is reported to have many extrapulmonary side effects. We are presenting a case of acute hypersensitivity pneumonitis (HP) secondary to DPH, presenting
Pallavi Periwal, Sharad Joshi, Rajesh Gothi, Deepak Talwar   +3 more
doaj   +2 more sources

Multidisciplinary approaches to identifying and managing global airways disease: Expert recommendations based on qualitative discussions

Frontiers in Allergy, 2023
BackgroundChronic rhinosinusitis with nasal polyps (CRSwNP) and asthma frequently co-exist and share pathologic features. Taking a “global” treatment approach benefits diagnosis and treatment of both, but care is often siloed by specialty: joined-up ...
Vibeke Backer, Lars Olaf Cardell, Lars Olaf Cardell, Lauri Lehtimäki, Lauri Lehtimäki, Sanna Toppila-Salmi, Leif Bjermer, Sietze Reitsma, Peter W. Hellings, Peter W. Hellings, Peter W. Hellings, Dan Weinfeld, Kasper Aanæs, Charlotte Suppli Ulrik, Charlotte Suppli Ulrik, Gert-Jan Braunstahl, Gert-Jan Braunstahl, Bernt Bøgvald Aarli, Bernt Bøgvald Aarli, Arild Danielsen, Hannu Kankaanranta, Hannu Kankaanranta, Hannu Kankaanranta, Sverre Steinsvåg, Claus Bachert, Claus Bachert, Claus Bachert   +26 more
doaj   +1 more source

Symptoms, physical findings and bronchial hypersensitivity in patients with bronchial asthma and normal spirometry [PDF]

Vojnosanitetski Pregled, 2009
Background/Aim. The diagnosis of bronchial asthma, a chronic inflammatory disease of the respiratory tract, is made on the basis of anamnesis, pathologic auscultatory findings of the lungs, lung function disturbances, skin tests, as well as the basic ...
Aćimović Slobodan, Plavec Goran, Tomić Ilija, Karličić Vukoica, Aćimović Svetlana, Vuković Jelena, Lončarević Olivera   +6 more
doaj   +1 more source

The relation between nonspecific hyperreactivity of the airways and atopic constitution in asthmatics [PDF]

Vojnosanitetski Pregled, 2016
Background/Aim. Hyperreactivity of the airways caused by inflammation in asthmatics is the most important pathophysiological change. It represents a suitable ground that in the presence of risk factors and the drivers of asthma, asthmatic attack occurs ...
Novković Dobrivoje, Petrović Marina, Živković Vladan, Baletić Nenad   +3 more
doaj   +1 more source

Cough hypersensitivity and suppression in COPD

, 2021
Cough reflex hypersensitivity and impaired cough suppression are features of chronic refractory cough (CRC). Little is known about cough suppression and cough reflex hypersensitivity in cough associated with chronic obstructive pulmonary disease (COPD ...
Fletcher, HV, Cho, PSP, Turner, RD, Birring, SS, Jolley, CJ, Patel, IS   +5 more
core   +1 more source