Results 51 to 60 of about 116,136 (342)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Integral-Based Identification of an Inhomogeneity Model in Respiratory Mechanics [PDF]

, 2012
4-pagesIndividualized models of respiratory mechanics may help to reduce potential harmful effects of ventilation therapy by predicting the outcome of certain ventilator settings.
Chase, J.G., Docherty, P.D., Möller, K., Schranz, C.   +3 more
core  

Randomized crossover comparison of proportional assist ventilation and patient-triggered ventilation in extremely low birth weight infants with evolving chronic lung disease [PDF]

, 2007
Background: Refinement of ventilatory techniques remains a challenge given the persistence of chronic lung disease of preterm infants. Objective: To test the hypothesis that proportional assist ventilation ( PAV) will allow to lower the ventilator ...
Andreas Schulze, Eduardo Bancalari, Esther Rieger-Fackeldey, Lebowitz HH, Musante G, Nelson Claure, Poon CS, Poon CS, Ruth Everett, Schaller P, Schulze A, Schulze A, Schulze A, Schulze A, Schulze A, Schulze A, Tilo Gerhardt, Younes M   +17 more
core   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Mechanical ventilation in chronic obstructive pulmonary disease patients, noninvasive vs. invasive method (randomized prospective study) [Usporedba neinvazivne i invazivne umjetne ventilacije kod bolesnika s kroničnom opstruktivnom plućnom bolesti: prospektivna randomizirana studija] [PDF]

, 2009
Acute respiratory failure due to chronic obstructive pulmonary disease (COPD) presents an increasing problem throughout the world. The aim of this study was to compare invasive and non-invasive mechanical ventilation (MV) for patients with COPD.
Buković, Damir, Jurjević, Matija, Matić, Ivo, Đanić, Davorin, Šakić, Šimun, Šakić-Zdravčević, Katarina   +5 more
core  

Propulsion in a viscoelastic fluid

, 2007
Flagella beating in complex fluids are significantly influenced by viscoelastic stresses. Relevant examples include the ciliary transport of respiratory airway mucus and the motion of spermatozoa in the mucus-filled female reproductive tract. We consider
Bird R. B., Bird R. B., Blake J. R., Blake J. R., Bray D., Denton R., Doi M., Dunn P. F., Eliezer N., Eric Lauga, Gelman R. A., Gilboa A., Giordano A. M., Gray J., Gueron S., Gueron S., Hayat T., Ho H. C., James S. L., Katz D. F., Katz D. F., King M., Larson R. G., Larson R. G., Lillehoj E. P., Liron N., Litt M., Litt M., Meyer F. A., Meyer F. A., Ross S. M., Shake M. P., Suarez S. S., Suarez S. S., Suarez S. S., Suarez S. S., Tam P. Y., Tanner R. I., Wolf D. P., Wolf D. P., Wolf D. P., Wolf D. P., Wolf D. P., Yates G. T.   +43 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

A fresh look at paralytics in the critically ill: real promise and real concern. [PDF]

, 2012
Neuromuscular blocking agents (NMBAs), or "paralytics," often are deployed in the sickest patients in the intensive care unit (ICU) when usual care fails.
Kenyon, Nicholas J, Price, David, Stollenwerk, Nicholas   +2 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Complex ventilation problems with no simple solution

Journal of Mechanical Ventilation, 2022
Editorial on the article: Alveolar mechanics: A new concept in respiratory ...
Ross Freebairn
doaj   +1 more source