Identification of urban particulate matter-induced disruption of human respiratory mucosa integrity using whole transcriptome analysis and organ-on-a chip [PDF]
Journal of Biological Engineering, 2019 Background Exposure to air particulate matter (PM) is associated with various diseases in the human respiratory system. To date, most in vitro studies showing cellular responses to PM have been performed in cell culture using a single cell type.
Junhyoung Byun +11 more
doaj +3 more sources
Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples. [PDF]
J Vis Exp, 2018 The methods of nasal absorption (NA) and bronchial absorption (BA) use synthetic absorptive matrices (SAM) to absorb the mucosal lining fluid (MLF) of the human respiratory tract.
Thwaites RS +11 more
europepmc +4 more sources
Leveraging 3D Model Systems to Understand Viral Interactions with the Respiratory Mucosa. [PDF]
Viruses, 2020 Respiratory viruses remain a significant cause of morbidity and mortality in the human population, underscoring the importance of ongoing basic research into virus–host interactions.
Iverson E +5 more
europepmc +4 more sources
The Development of a Human Respiratory Mucosa-on-a-Chip Using Human Turbinate-Derived Mesenchymal Stem Cells [PDF]
MedicinaBackground and Objectives: This study aimed to investigate the influence of a respiratory mucosa-on-a-chip on the respiratory epithelial differentiation potential of human nasal inferior turbinate-derived stem cells (hNTSCs). Materials and Methods: After
Do Hyun Kim +7 more
doaj +3 more sources
Early Th2 inflammation in the upper respiratory mucosa as a predictor of severe COVID-19 and modulation by early treatment with inhaled corticosteroids: a mechanistic analysis. [PDF]
Lancet Respir Med, 2022 Baker JR +9 more
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IgA polymerization contributes to efficient virus neutralization on human upper respiratory mucosa after intranasal inactivated influenza vaccine administration [PDF]
Human Vaccines & Immunotherapeutics, 2018 Unlike the current injectable influenza vaccines, intranasally administered influenza vaccines induce influenza virus-specific IgA antibodies in the local respiratory mucosa as well as IgG antibodies in the systemic circulation. Our previous study showed
Yoshihiko Terauchi +11 more
doaj +3 more sources
SARS-CoV-2: The Road Less Traveled-From the Respiratory Mucosa to the Brain. [PDF]
ACS Omega, 2021 Neurological manifestations have been reported in COVID-19; however, the route used by SARS-CoV-2 to enter the brain is still under debate. Recent studies have focused on the olfactory route.
Arunachalam JP +4 more
europepmc +2 more sources
Gene expression and immunochemical localization of major cytochrome P450 drug-metabolizing enzymes in bovine nasal olfactory and respiratory mucosa. [PDF]
Inhal Toxicol, 2015 Dhamankar V, Assem M, Donovan MD.
europepmc +4 more sources
The Role of Immunobiotics and Postbiotics in the Recovery of Immune Cell Populations From Respiratory Mucosa of Malnourished Hosts: Effect on the Resistance Against Respiratory Infections. [PDF]
Front Nutr, 2021 Malnutrition is associated with a state of secondary immunodeficiency, which is characterized by a worsening of the immune response against infectious agents. Despite important advances in vaccines and antibiotic therapies, the respiratory infections are
Salva S +4 more
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Neutrophilic inflammation in the respiratory mucosa predisposes to RSV infection. [PDF]
Science, 2020 ACHOO!-trophils? Why some individuals come down with a cold in any given year, whereas others are spared, is poorly understood. Habibi et al. exposed volunteers to respiratory syncytial virus (RSV), one of the pathogens responsible for the common cold ...
Habibi MS +16 more
europepmc +2 more sources