Identification of urban particulate matter-induced disruption of human respiratory mucosa integrity using whole transcriptome analysis and organ-on-a chip [PDF]
Journal of Biological Engineering, 2019 Background Exposure to air particulate matter (PM) is associated with various diseases in the human respiratory system. To date, most in vitro studies showing cellular responses to PM have been performed in cell culture using a single cell type.
Junhyoung Byun +11 more
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The Development of a Human Respiratory Mucosa-on-a-Chip Using Human Turbinate-Derived Mesenchymal Stem Cells [PDF]
MedicinaBackground and Objectives: This study aimed to investigate the influence of a respiratory mucosa-on-a-chip on the respiratory epithelial differentiation potential of human nasal inferior turbinate-derived stem cells (hNTSCs). Materials and Methods: After
Do Hyun Kim +7 more
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Pseudomonas aeruginosa adhesion to normal and injured respiratory mucosa [PDF]
Memorias do Instituto Oswaldo Cruz, 1992 Human nasal polyps outgrowth culture were used to study the adhesion of Pseudomonas aeruginosa to respiratory cells. By transmission electron microscopy, bacteria associated with ciliated cells were identified trapped at the extremities of cilia, usually
M. C. Plotkowski +3 more
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Bioengineering Human Upper Respiratory Mucosa: A Systematic Review of the State of the Art of Cell Culture Techniques [PDF]
BioengineeringBackground: The upper respiratory mucosa plays a crucial role in both the physical integrity and immunological function of the respiratory tract. However, in certain situations such as infections, trauma, or surgery, it might sustain damage.
Davaine Joel Ndongo Sonfack +7 more
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IgA polymerization contributes to efficient virus neutralization on human upper respiratory mucosa after intranasal inactivated influenza vaccine administration [PDF]
Human Vaccines & Immunotherapeutics, 2018 Unlike the current injectable influenza vaccines, intranasally administered influenza vaccines induce influenza virus-specific IgA antibodies in the local respiratory mucosa as well as IgG antibodies in the systemic circulation. Our previous study showed
Yoshihiko Terauchi +11 more
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The Respiratory Mucosa: Front and Center in Respiratory Syncytial Virus Disease. [PDF]
Am J Respir Crit Care Med, 2019 Thwaites RS, Openshaw PJ.
europepmc +3 more sources
The Safety of Topical and Intravenous Tranexamic Acid in Endoscopic Sinus Surgery
Sinusitis, 2022 Tranexamic acid (TXA) is an inexpensive and widely used medication indicated for the reduction of bleeding. There are data showing the efficacy of intravenous (IV) and topical TXA in endoscopic sinus surgery (ESS) but the safety of this practice is not ...
Agrani Ratnayake Kumar +1 more
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Frontiers in Pharmacology, 2022 Spirulina platensis has shown effectiveness in the treatment of allergic rhinitis in rats, but its action in tracheal reactivity or on markers of relaxation and antioxidant profile has not yet been possible to determine.
Aline de F. Brito +10 more
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Mucosal Immune Responses to Respiratory Syncytial Virus
Cells, 2022 Despite over half a century of research, respiratory syncytial virus (RSV)-induced bronchiolitis remains a major cause of hospitalisation in infancy, while vaccines and specific therapies still await development.
Megan V. C. Barnes +2 more
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Nasal Lipopolysaccharide Challenge and Cytokine Measurement Reflects Innate Mucosal Immune Responsiveness [PDF]
, 2015 BackgroundPractical methods of monitoring innate immune mucosal responsiveness are lacking. Lipopolysaccharide (LPS) is a component of the cell wall of Gram negative bacteria and a potent activator of Toll-like receptor (TLR)-4.
Dhariwal, J +12 more
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