Results 121 to 130 of about 1,103,603 (282)

Neuromuscular and neuromechanical assessments of respiratory performance in the mdx mouse model of Duchenne muscular dystrophy across the natural history of disease

open access: yesExperimental Physiology
Duchenne muscular dystrophy (DMD) is a severe life‐limiting X‐linked neuromuscular disorder characterised by progressive skeletal muscle degeneration and respiratory failure. The mdx mouse, lacking dystrophin, is the most widely used preclinical model of
Michael N. Maxwell   +4 more
doaj   +1 more source

Nano‐Backpack Engineered Probiotics with Reactive Oxygen Species–Responsive Tungsten Release for Synergistic Therapy of Inflammatory Bowel Disease

open access: yesAdvanced Science, EarlyView.
An integrated probiotic system is engineered to execute a programmed therapeutic cascade against inflammatory bowel disease. Upon pathological signals, the system sequentially performs ROS scavenging, tungsten release, and selective pathogen suppression, thereby breaking the oxidative stress–dysbiosis cycle to remodel gut microbiota and reinforce ...
Yang Yang   +8 more
wiley   +1 more source

Respiratory performance in Duchenne muscular dystrophy: Clinical manifestations and lessons from animal models

open access: yesExperimental Physiology
Duchenne muscular dystrophy (DMD) is a fatal genetic neuromuscular disease. Lack of dystrophin in skeletal muscles leads to intrinsic weakness, injury, subsequent degeneration and fibrosis, decreasing contractile function.
Rebecca Delaney, Ken D. O'Halloran
doaj   +1 more source

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

open access: yesAdvanced Science, EarlyView.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu   +8 more
wiley   +1 more source

Arterial Blood‐Mediated Deep‐Tissue Photoacoustic Oximetry

open access: yesAdvanced Science, EarlyView.
The arterial prior method (APM+) for photoacoustic oximetry is introduced, which leverages the high arterial blood oxygenation to calibrate the fluence at the artery and estimate the oxygenation of the surrounding tissue, thus circumventing the spectral coloring problem. APM+’s accuracy and consistency are shown in a series of phantom and in vivo human
Karteekeya Sastry   +7 more
wiley   +1 more source

The Influence of Surgical Correction of Idiopathic Scoliosis on the Function of Respiratory Muscles. [PDF]

open access: yesJ Clin Med, 2022
Jasiewicz B   +4 more
europepmc   +1 more source

Respiratory Muscles and Muscle Strengthening.

open access: yesRigakuryoho Kagaku, 2003
呼吸筋力の測定には,最大口腔内圧を用いることが一般的である。最大口腔内圧は様々な因子で変化するが,肺気量の変化が最も大きな影響を及ぼす。この呼吸筋力の低下は肺胞低換気による高炭酸ガス血症を伴う低酸素血症の原因となるため,呼吸器疾患を持つ患者には重要である。呼吸筋力はいくつかの原因で低下するが,閉塞性換気障害と拘束性換気障害を例に取り解説する。呼吸筋力低下がもたらす症状を持つ患者にとってその改善は重要であるが,そのトレーニング方法についても紹介する。
openaire   +2 more sources

Metagenomic Association Uncovers Host Genotype‐Structured Rhizobacterial Networks and Novel Taxa That Enhance Soybean Salt Tolerance

open access: yesAdvanced Science, EarlyView.
An STI‐guided metagenomic association framework links soybean salt‐tolerance phenotypes with rhizosphere microbiome composition and network organization in natural saline soils. The approach identifies candidate beneficial taxa, including Thalassospira xiamenensis, and provides an efficient strategy for mining stress‐protective microbes from native ...
Yu Luo   +3 more
wiley   +1 more source

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