Results 31 to 40 of about 148,278 (306)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Exercise-induced respiratory muscle work: Effects on blood flow, fatigue and performance

, 2008
This is the post print version of this article. The official published version can be obtained from the link below.In healthy subjects, heavy intensity endurance exercise places substantial demands on the respiratory muscles as breathing frequency ...
C. A. Smith, Romer, L, J. A. Dempsey, L. Romer, J. D. Miller, Miller, JD, Smith, CA, Dempsey, JA, M. Amann, Amann, M   +9 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Automatic electrical stimulation of abdominal wall muscles increases tidal volume and cough peak flow in tetraplegia [PDF]

, 2008
<p>Paralysis of the respiratory muscles in people with tetraplegia affects their ability to breathe and contributes to respiratory complications.
Hunt, K.J., Fraser, M.H., Gollee, H., Allan, D.B., McLean, A.N.   +4 more
core  

Determinants of inspiratory muscle strength in healthy humans [PDF]

, 2014
We investigated 1) the relationship between the baseline and inspiratory muscle training (IMT) induced increase in maximal inspiratory pressure (PI,max) and 2) the relative contributions of the inspiratory chest wall muscles and the diaphragm (Poes/Pdi ...
Brown, PI, Johnson, MA, Sharpe, GR
core   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

Respiratory muscles during ventilatory support

, 1994
Knowledge of the fate and behaviour of the respiratory muscles during ventilatory support is important for the guidance of clinical care. Full support facilitates muscle metabolic repletion, but exposes them to the risk of disuse atrophy.
Fitting, J. W.
core   +1 more source

Peripheral and respiratory muscle impairment during murine acute lung injury

Physiological Reports, 2022
Acute respiratory distress syndrome is associated with skeletal muscle compromise, which decreases survival and impairs functional capacity. A comparative analysis of peripheral and respiratory muscles' atrophy and dysfunction in acute lung injury (ALI ...
Martín Angulo, Agustina Vacca, Romina Rodríguez, María Noel Marin, Ana Laura Suárez, Gissel Jorge, Oscar Nosiglia, Victoria Cambón, Anaclara Ríos, Matías Iglesias, Mariana Seija, Carlos Escande, Javier Hurtado, Arturo Briva   +13 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The effects of inspiratory muscle training on plasma interleukin-6 concentration during cycling exercise and a volitional mimic of the exercise hyperpnea

, 2013
It is unknown whether the respiratory muscles contribute to exercise-induced increases in plasma interleukin-6 (IL-6) concentration, if this is related to diaphragm fatigue, and whether inspiratory muscle training (IMT) attenuates the plasma IL-6 ...
Gonzalez, JT, Mills, Dean E., Gonzalez, Javier T., Neil C. Williams, Sharpe, GR, Sharpe, Graham R., McPhilimey, Martin J., Williams, NC, Mills, Dean, Gonzalez, Javier, McPhilimey, Martin, McPhilimey, MJ, Johnson, Michael A., Yvonne A. Barnett, Graham R. Sharpe, Barnett, YA, Martin J. McPhilimey, Mills, DE, Barnett, Yvonne, Javier T. Gonzalez, Sharpe, Graham, Williams, Neil C., Dean E. Mills, Johnson, MA, Barnett, Yvonne A., Michael A. Johnson, Williams, Neil   +26 more
core   +1 more source