Results 81 to 90 of about 1,201,684 (350)

Switching patients from other inhaled corticosteroid devices to the Easyhaler(®) : historical, matched-cohort study of real-life asthma patients [PDF]

, 2014
Peer reviewedPublisher ...
Gould, Shuna, Hutton, Catherine, King, Christine, Price, David, Thomas, Vicky, von Ziegenweidt, Julie   +5 more
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

A high content, phenotypic ‘scar-in-a-jar’ assay for rapid quantification of collagen fibrillogenesis using disease-derived pulmonary fibroblasts

BMC Biomedical Engineering, 2019
Background Excessive extracellular matrix (ECM) deposition is a hallmark feature in fibrosis and tissue remodelling diseases. Typically, mesenchymal cells will produce collagens under standard 2D cell culture conditions, however these do not assemble ...
Robert B. Good, Jessica D. Eley, Elaine Gower, Genevieve Butt, Andrew D. Blanchard, Andrew J. Fisher, Carmel B. Nanthakumar   +6 more
doaj   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Why Saudi Respiratory Therapists Struggle with Research: An Evidence-Based Analysis

Advances in Medical Education and Practice
Mohammed M Alqahtani,1– 3 Hassan Aljohani,1– 3 Saleh S Algarni,1– 3 Mobarak K Alqahtani,1– 3 Taha T Ismaeil,1– 3 Mutab F Alotaibi,1,3 Fahad H Al Enazi,4,5 Turki M Alanazi,4,5 Ziyad F Al Nufaiei6– 8 1Department of Respiratory Therapy, College of Applied ...
Alqahtani MM, Aljohani H, Algarni SS, Alqahtani MK, Ismaeil TT, Alotaibi MF, Al Enazi FH, Alanazi TM, Al Nufaiei ZF   +8 more
doaj  

Rationale for Prolonged Glucocorticoid Use in Pediatric ARDS: What the Adults Can Teach Us. [PDF]

, 2016
Based on molecular mechanisms and physiologic data, a strong association has been established between dysregulated systemic inflammation and progression of acute respiratory distress syndrome (ARDS).
Meduri, Gianfranco Umberto, Schwingshackl, Andreas   +1 more
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

The Associations of Anaemia Status and Body Mass Index with Asthma Severity in Saudi Arabia: A Comparative Study

Journal of Asthma and Allergy
Alaa A Bugis,1– 3 Bussma Bugis,4 Abdulsalam Alzahrani,1– 3 Ali Hasan Alamri,1– 3 Hamad Hani Almalki,1– 3 Jamal Hassan Alshehri,1– 3 Abdullah Ali Alqarni,1– 3 Faisal A Turkestani1– 3,5 1Respiratory Therapy Program, College of Applied Medical Sciences ...
Bugis AA, Bugis B, Alzahrani A, Alamri AH, Almalki HH, Alshehri JH, Alqarni AA, Turkestani FA   +7 more
doaj  

Comparative assessment of respiratory, hematological and inflammatory profiles of long-term users of cigarettes, shisha, and e-cigarettes in Saudi Arabia

Tobacco Induced Diseases
Introduction Globally, over 1 billion people smoke, resulting in approximately 8 million deaths each year. Although the health risks associated with traditional cigarettes are extensively documented, there is an increasing need to evaluate the long-term ...
Mazen M. Homoud, Rowaida Qoutah, Gokul Krishna, Noran Harbli, Layan Saaty, Afrah Obaidan, Abdulrahman Alkhathami, Noran Jamil, Tala Μ. Alkayyat, Maryam Alsughayyir, Nada Gubari, Saleh Alkhathami, Ali Alqarni, Omar Alqurashi, Khalid Assiri, Khalid Saeed Alwadeai, Wafaa Abdulrahman, Husam Alahmadi, Ayedh Alahmari   +18 more
doaj   +1 more source