Results 91 to 100 of about 2,828,940 (313)

Intracellular Formation of Synthetic Peptide Nanostructures Causes Mitochondrial Disruption and Cell Death in Tumor Spheroids

open access: yesAdvanced Science, EarlyView.
Synthetic peptide nanostructures, formed within cancer cells in response to glutathione, lead to mitochondrial dysfunction and cell death. The nanostructures significantly damage mitochondrial networks, impair cellular respiration, and induce cell death in both 2D cultures and 3D tumor spheroids.
Sarah Chagri   +13 more
wiley   +1 more source

Serological Evidence of Infection with Respiratory Viruses in 1954-5 [PDF]

open access: green, 1956
P. J. Wormald   +2 more
openalex   +1 more source

Viruses and Acute Respiratory Infections

open access: yesBMJ, 1965
The most common infectious diseases in Western urban communities are acute infections of the respiratory tract, and most of these are because of viruses. The viruses enter the ciliated and other cells lining the respiratory tract, multiplying there and damaging the cells.
openaire   +2 more sources

Neuraminidase 1 Exacerbated Glycolytic Dysregulation and Cardiotoxicity by Destabilizing SIRT1 through Interactions with NRF2 and HIF1α

open access: yesAdvanced Science, EarlyView.
NEU1, a key regulator of glycolysis, is markedly upregulated following DOX treatment. This upregulation is attributed to HIF1α’s transcriptional repression, requiring intricate interactions with NRF2. Increased NEU1 facilitates SIRT1 lysosomal degradation, contributing to aberrant glycolytic phenotype and cardiac damage.
Ting Gao   +13 more
wiley   +1 more source

The Lung Microbiome Modulates Pain‐Like Behavior Via the Lung–Brain Axis in a Nitroglycerin‐Induced Chronic Migraine Mouse Model

open access: yesAdvanced Science, Volume 12, Issue 23, June 20, 2025.
Intratracheal neomycin alters pulmonary microbiota, activating the vagus nerve via lung brain‐derived neurotrophic factor/tropomyosin receptor kinase B (BDNF/TrkB) pathway, further projecting to nucleus of solitary tract (NTS), then dorsal raphe nucleus (DRN), where activated serotoninergic neurons increase brain serotonin, alleviating migraine.
Biying Liu   +7 more
wiley   +1 more source

Post‐Translational Modifications in Cilia and Ciliopathies

open access: yesAdvanced Science, EarlyView.
This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley   +1 more source

Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia‐Inducible Factor‐1 Signaling Pathway

open access: yesAdvanced Science, EarlyView.
This study investigates the role of macrophage pyruvate carboxylase (PC) in atherosclerosis (AS) demonstrating that PC upregulation in macrophages promotes metabolism reprogramming to enhance inflammatory responses via the HIF‐1 signaling pathway.
Ling‐Na Zhao   +17 more
wiley   +1 more source

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