Results 121 to 130 of about 3,116,161 (404)

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

Biochemical analysis of packing and assembling heptad repeat motifs in the coronavirus spike protein trimer

mBio
During a coronavirus infection, the spike protein undergoes sequential structural transitions triggered by its receptor and the host protease at the interface between the virus and cell membranes, thereby mediating membrane fusion. After receptor binding,
Jun Kobayashi, Kazuhiko Kanou, Hiyori Okura, Tahmina MST Akter, Shuetsu Fukushi, Shutoku Matsuyama   +5 more
doaj   +1 more source

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source

Experimental validation and computational modeling of anti-influenza effects of quercetin-3-O-α-L-rhamnopyranoside from indigenous south African medicinal plant Rapanea melanophloeos

BMC Complementary and Alternative Medicine, 2019
Background Influenza A virus (IAV) is still a major health threat. The clinical manifestations of this infection are related to immune dysregulation, which causes morbidity and mortality.
Parvaneh Mehrbod, Samad Nejad Ebrahimi, Fatemeh Fotouhi, Fatemeh Eskandari, Jacobus N. Eloff, Lyndy J. McGaw, Folorunso O. Fasina   +6 more
doaj   +1 more source

The late arrival of coronavirus disease 2019 (COVID-19) in Chad: mitigating spread in Ndjamena focused on specific target population

The Pan African Medical Journal, 2020
The novel coronavirus disease 2019 (COVID-19) has rapidly spread to all 7 continents. Due to yet unknown reasons, the African continent has remained relatively unaffected, especially Chad.
Zita Aleyo Nodjikouambaye, Chatté Adawaye, Fissou Henry Yandai, Laurent Bélec   +3 more
doaj   +1 more source

Altered expression of cytokines in mice infected intranasally with two syncytial variants of Herpes simplex virus type 1 [PDF]

, 2014
Immune evasion strategies are important for the onset and the maintenance of viral infections. Many viruses have evolved mechanisms to counteract or suppress the host immune response.
Adler, Ankel, Artuso, Canalejo Castrillero, Carlos A. Pujol, Carlucci, Chew, Chiang, Ellermann-Eriksen, Finton, Florencia N. Linero, Glorieux, Hull, Karasneh, Lucey, Luis A. Scolaro, M. Carolina Artuso, M. Josefina Carlucci, Martinez, Mateu, Mogensen, Murphy, Nandakumar, Opal, Paludan, Reading, Romagnani, Rosa Wainstok, Silvina Gazzaniga, Smyth, Stumpf, Teng   +31 more
core   +2 more sources

Using routine testing data to understand circulation patterns of influenza A, respiratory syncytial virus and other respiratory viruses in Victoria, Australia

Epidemiology and Infection, 2019
Several studies have reported evidence of interference between respiratory viruses: respiratory viruses rarely reach their epidemic peak concurrently and there appears to be a negative association between infection with one respiratory virus and co ...
Olivia H Price, Sheena G. Sullivan, C. Sutterby, J. Druce, K. Carville   +4 more
semanticscholar   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

In vitro and in vivo expression of foreign genes by transmissible gastroenteritis coronavirus-derived minigenomes [PDF]

, 2002
A helper-dependent expression system based on transmissible gastroenteritis coronavirus (TGEV) has been developed using a minigenome of 3·9 kb (M39).
Alonso, S., Balasch, M., Enjuanes, L., Izeta, A., Moormann, R.J.M., Plana Duran, J., Reimann, I., Sola, I., Teifke, J.P.   +8 more
core   +3 more sources

Respiratory Viruses Dynamics and Interactions: Ten Years of Surveillance in Central Europe [PDF]

, 2021
Gibran Horemheb-Rubio, Ralf Eggeling, Norbert Schmeißer, Nico Pfeifer, Thomas Lengauer, Barbara C. Gärtner, Christiane Prifert, Matthias Kochanek, Christoph Scheid, Ortwin Adams, Rolf Kaiser   +10 more
openalex   +1 more source