Results 131 to 140 of about 297,224 (307)

Impact of the COVID-19 related border restrictions on influenza and other common respiratory viral infections in New Zealand

BackgroundNew Zealand's (NZ) complete absence of community transmission of influenza and respiratory syncytial virus (RSV) after May 2020, likely due to COVID-19 elimination measures, provided a rare opportunity to assess the impact of border ...
Fahey, Jennifer, McIntosh, Christine, Jennings, Tineke, Seeds, Ruth, Wood, Tim, Tan, Chor Ee, Ren, Xiaoyun, Turner, Nikki, Caballero, Ernest, Stanley, Alicia, Daniells, Karen, Webby, Richard J, Lawrence, Shirley, O'Neill, Meaghan, Antoszewska, Hanna, Thomas, Paul G, Rensburg, Megan, Mansell, Chris, Anglemyer, Andrew, Geoghegan, Jemma, Marull, Maritza, de Ligt, Joep, Addidle, Michael, Berquist, Klarysse, Huang, Q Sue, Trenholme, Adrian, McArthur, Colin, Balm, Michelle, Grant, Jenny, Kvalsvig, Amanda, McIntyre, Peter, Werno, Anja, Roberts, Sally, Yu, Chang, Taylor, Susan, Dowell, Tony, Byrnes, Cass, BorderRestrictionImpactOnFluRSV Consortium, Jelley, Lauren, Penghulan, Emmanuel, Nesdale, Annette, Wong, Conroy, Elvy, Juliet, Aminisani, Nayyereh, Jefferies, Sarah, Kiedrzynski, Tomasz, Cueto, Jort, McAuliffe, Gary, Zacchi, Nicolas, Campbell-Stokes, Priscilla, Baker, Michael G, Dilcher, Meik, McNeill, Andrea, Van Der Werff, Koen, Widdowson, Marc-Alain, John, Joshma, Grant, Cameron C, Dobinson, Hazel C   +57 more
core   +1 more source

Identification of New Respiratory Viruses in the New Millennium

, 2015
The rapid advancement of molecular tools in the past 15 years has allowed for the retrospective discovery of several new respiratory viruses as well as the characterization of novel emergent strains.
Fielding, Burtram, Junaid Gamieldien, Michael Berry, Gamieldien, Junaid, Fielding, Burtram C., Burtram Fielding, Burtram C. Fielding, Berry, Michael   +7 more
core   +1 more source

Electron microscopy images and morphometric data of SARS-CoV-2 variants in ultrathin plastic sections

Scientific Data
Conventional thin section electron microscopy of viral pathogens, such as the pandemic SARS-CoV-2, can provide structural information on the virus particle phenotype and its evolution.
Tobias Hoffmann, Janine Michel, Andreas Nitsche, Christin Mache, Jessica Schulze, Thorsten Wolff, Michael Laue   +6 more
doaj   +1 more source

Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells

Advanced Science, EarlyView.
In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu, Wenhao Zhang, Yifan Zhang, Yu He, Yi Du, Yiding Zhao, Chunmeng Yao, Shengyi Sun, Xiaoyan Sheng, Qian Gao, Chao Tong, Ling Shuai   +11 more
wiley   +1 more source

Peramivir and laninamivir susceptibility of circulating influenza A and B viruses

, 2013
Influenza viruses collected from regions of Asia, Africa and Oceania between 2009 and 2012 were tested for their susceptibility to two new neuraminidase inhibitors, peramivir and laninamivir. All viruses tested had normal laninamivir inhibition. However,
Kwok, Simon, Hurt, Aeron C., Barr, Ian G., Maurer-Stroh, Sebastian, Kelso, Anne, Sullivan, Sheena G., Leang, Sook-Kwan   +6 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Honey as an antiviral agent against respiratory syncytial virus

, 2011
Respiratory syncytial virus is the most frequent cause of hospitalization for viral respiratory infections in infants and young children worldwide. It also severely affects immunocompromised adults and the elderly, however, despite decades of efforts ...
Zareie, Parvaneh Palma
core  

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

SERS Facemask for Rapid and Portable Sensing Mycobacterium Tuberculosis Antigens for TB Screening

Advanced Science, EarlyView.
Our study introduced an Au─Ag embedded covalent organic framework (U@COF) ‐mediated facemask for sensing TB antigen ESAT‐6/CFP‐10 complex in clinical droplet samples toward TB screening. Practical analysis of clinical samples demonstrated the availability of our facemask, which is capable of identifying the TB subjects (N = 17) from healthy candidates (
Lingzhi Chen, Jiaqi Yu, Jing Xu, Lingqi Chen, Ninghao Zhang, Wenrui Li, Runmin Zeng, Xiaomin Luo, Yiqun Chang, Jiayin Lai, Wenshi Huang, Xiaochen Liang, Ting Zhao, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Xueqin Huang, Haibo Zhou, Junxia Zheng   +20 more
wiley   +1 more source