Results 151 to 160 of about 1,320,014 (285)

Target-Based Antiviral Drug Development Against Human Respiratory Viruses. [PDF]

Pathogens
Samrat SK, Srivastava G, Zhang R, Li Z, Li H.   +4 more
europepmc   +1 more source

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee, Gayeon Kim, Ellison R. Black, Seonil Kim   +3 more
wiley   +1 more source

Detection of Respiratory Viruses in Wastewater Samples Using Commercial Multiplex PCR Assays. [PDF]

Viruses
Sberna G, Petricciuolo M, Camilloni B, Lalle E, Carnevali A, Smoquina F, Graziani A, Brillo F, Fabeni L, Valli MB, Rueca M, Federici E, Maggi F, Berno G.   +13 more
europepmc   +1 more source

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

Advanced Science, EarlyView.
After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma, Changyuan Kang, Xixian Liu, Lichao Yang, Mengyi Li, Yuting Ye, Jianfang Zhang, Yingjun Li, Guanghui Jin, Yang Liu, Xiaohong Chen, Kexin Wang, Zifeng Yang   +12 more
wiley   +1 more source

Seasonal respiratory viruses in adult ICU patients

, 2017
Respiratory viruses are frequently detected in adult patients admitted to the intensive care unit (ICU) and are increasingly being recognised for their role as causal agents in severe respiratory tract infections.
van Someren Gréve, F., Medical Microbiology, Ong, D. S.Y., MMB opleiding Arts microbioloog   +3 more
core  

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

Optimization of the antiviral spectrum of cyclophilin inhibitors targeting respiratory viruses. [PDF]

Antimicrob Agents Chemother
Softic L, Jimenez-Araya B, Ahnou N, Duval M, Nevers Q, Brillet R, Guichou J-F, Rodriguez C, Bruscella P, Pawlotsky J-M, Fourati S, Ahmed-Belkacem A.   +11 more
europepmc   +1 more source

Respiratory viruses

, 2012
Korsman, Stephen N.J., van Zyl, Gert U., Nutt, Louise, Andersson, Monique I., Preiser, Wolfgang   +4 more
openaire   +1 more source

A Molecularly Defined Midbrain Circuit Mechanism for Sound‐Driven Defensive Behavior and Anxiety

Advanced Science, EarlyView.
Schematic diagram showing the Cbln2+ ICx–dPAG circuit for sound‐driven defensive and anxiety‐like behaviors. ABSTRACT The innate defense behaviors in response to threatening sounds play a fundamental role in survival. However, the neural circuits that detect threat‐relevant auditory cues and transform them into defensive behaviors remain poorly defined.
Jie Cao, Xingxing Lai, Lifang Huo, Zhouyuan Zheng, Qian Zhang, Zhimin Ye, Panpan Wan, Chao Ma, Congping Shang   +8 more
wiley   +1 more source

Respiratory Viruses, Self-Diagnosis, Early Treatment and Prophylaxis. [PDF]

Viruses
Puigdellívol-Sánchez A, Lozano-Paz C, Valls-Foix R, Morán-Blanco I, Calicó-Bosch I, Castells M.   +5 more
europepmc   +1 more source