Results 171 to 180 of about 297,224 (307)

A Non‐Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development

Advanced Science, EarlyView.
SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang, Chen Lian, Xinyan Han, Xuhan Zhang, Zihan Wang, Boyu Wang, Taoyu Zhu, Xinrui Lin, Xiaolei Wang, Yaping Xu, Manyu Xiao, Zijin Wang, Junming Li, Silin Chen, Yunze Wang, Yufei Liu, Songsong Li, Zuolin Shen, Xi Lu, Xueqi Han, Yilu Zhou, Mingyang Xiao, Jiayi Ran, Xiaoran Cao, Xinyi Xu, Hugo Sámano‐Sánchez, Alfredo Rodríguez, Lian Wang, Shuifang Chen, Zhanyu Xu, Shirong Zhang, Nuo Yang, Yong Tang, Jian Liu   +33 more
wiley   +1 more source

Detection and Genomic Characterization of Novel Respiratory Viruses in US and Mexican Cattle Farms. [PDF]

Transbound Emerg Dis
Oguzie JU, Cummings DB, Groves JT, Hagan AG, Rodriguez J, Hernandez-Vidal G, Moreno-Degollado G, Shittu I, Marushchak LV, Nguyen-Tien T, Trujillo-Vargas CM, Silva DB, Li F, Richeson JT, Schneider NE, Gray GC.   +15 more
europepmc   +1 more source

Discovery and Engineering of a Rat Endogenous Retrovirus Reverse Transcriptase for Efficient Prime Editing

Advanced Science, EarlyView.
We screened 558 reverse transcriptases and engineered an optimized rat endogenous retrovirus‐derived variant, enRERV‐RT, via structure‐guided engineering and deep mutational scanning. This enhanced prime editor, based on the engineered RT, outperforms conventional M‐MLV‐RT systems across plant and animal cells, particularly at hard‐to‐edit loci ...
Linsha Ma, Pengcheng Yao, Shengqi Wu, Yuanyuan Shi, Lang Qin, Baitao Li, Jiayi Zhu, Minhua Huang, Yichong Zhu, Yuwen Song, Jinhuan Pang, Ziping Guo, Guochuan Wu, Chen Wang, Kewei Xu, Ruihua Huang, Quan Kuang, Liang Qu, Changtian Pan, Xianrong Xie, Qinlong Zhu, Jiaying Huang, Qiupeng Lin   +22 more
wiley   +1 more source

Probenecid is a dual-acting antiviral/anti-inflammatory therapy for diverse respiratory viruses. [PDF]

Front Pharmacol
Tripp RA, Jones LP, Martin DE.
europepmc   +1 more source

ProSiteHunter: A Unified Framework for Sequence‐Based Prediction of Protein‐Nucleic Acid and Protein‐Protein Binding Sites

Advanced Science, EarlyView.
This study proposed a unified sequence‐based framework for protein binding site prediction, which adopted a tri‐track semantic multi‐source feature fusion strategy to effectively capture diverse macromolecular interaction sites and further improved the accuracy of antibody‐antigen interaction prediction.
Dongliang Hou, Qihang Zhen, Zexin Lv, Xinyue Cui, Suhui Wang, Minghua Hou, Zhan Zhou, Xiaogen Zhou, Guijun Zhang   +8 more
wiley   +1 more source

Internalization-related host factors of common respiratory viruses. [PDF]

Front Immunol
Lv Q, Xie Z, Xu L.
europepmc   +1 more source

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

RAZOR: a database of PCR primers targeting human respiratory viruses. [PDF]

NAR Genom Bioinform
Gill HM, Mir Q, Srivastava R, Janga SC.
europepmc   +1 more source

From Defense Executor to Engineering Target: Harnessing Lignin for Crop Resistance

Advanced Science, EarlyView.
Lignin serves as both a physical and chemical executor of broad‐spectrum plant immunity. This review systematically summarizes classical and recent advances in lignin‐mediated immunity, outlines the multifaceted regulatory modules controlling lignification under biotic stress, discusses key physiological and biochemical mechanisms behind lignin‐based ...
Yanwen Yu, Ke Wang, Huachuan Tuo, Jiankun Li, Liping Xu, Chang‐Jun Liu, Mingyue Gou   +6 more
wiley   +1 more source

Immunosenescence and susceptibility to respiratory viruses: a state-of-the-art review. [PDF]

Eur Respir Rev
Fragkou PC, Skevaki C, Moschopoulos CD, Keske Ş, Wozniak H, Malézieux-Picard A, Prendki V, Rello J, ESCMID Study Group for Respiratory Viruses (ESGREV) and the ESCMID Study Group for Infections in the Elderly (ESGIE).   +8 more
europepmc   +1 more source