Results 161 to 170 of about 297,224 (307)

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

Circulation of Influenza and Other Respiratory Viruses in Tunisia, 2022-2023 Season. [PDF]

Influenza Other Respir Viruses
Zoubeir B, Hind B, Sonia D, Salma A, Rachel WE, Hakim EG, Rihab Y, Nacef BM, Amal M, Ichrak B, Emna E, Najla BS, El Houda GN, Radhouane T, Leila B, Chokri BH, Takoua M, Mohamed B, Mounir BJ, Khaled M, Jalila BK, Nissaf BA, Afif BS, Dhafer L, Kinda Z, Ilhem BB.   +25 more
europepmc   +1 more source

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

Detection of respiratory viruses and efficacy of face masks in reducing viral release in human exhaled breath

, 2018
Background: Respiratory viruses are associated with considerable morbidity and mortality globally. They have been detected from infected patients while breathing, speaking and coughing, but there is little data on the efficacy of facemasks to filter ...
Shiu, EYC, Leung, NHL, Ip, DKM, Hau, BJP, Seto, WH, Mcdevitt, JJ, Chu, KW, Yen, H, Li, Y, Peiris, JSM, Milton, DK, Cowling, BJ, Leung, GM, Chan, KH   +13 more
core  

Modeling the risk of airborne transmission of respiratory viruses in microgravity. [PDF]

NPJ Microgravity
Sararat C, Jiravejchakul N, Nawattanapaiboon K, Modchang C.   +3 more
europepmc   +1 more source

Macrophage‐to‐Myofibroblast Transdifferentiation Contributes to Pulmonary Fibrosis via the MERTK‐SPP1‐SRC‐TKS5 Signaling Axis

Advanced Science, EarlyView.
MERTK is upregulated in fibrotic macrophages and regulates the expression and activity of SRC and TKS5 through SPP1, mediating transdifferentiation of macrophages‐to‐myofibroblasts (MMT) and promoting pulmonary fibrosis. The figure was created with BioRender.com.
Yungeng Wei, Hua Guo, Xiangsheng Yang, Xiao Xiao Tang   +3 more
wiley   +1 more source

CRISPR-Cas12a2-Based Multiplexed Diagnostic for Rapid and Highly Sensitive Detection of Respiratory Viruses. [PDF]

Anal Chem
Liu C, Feng M, Yu H, Zhang X, Li Y, Sui G, Jing W, Cheng X.   +7 more
europepmc   +1 more source

Ferritinophagy Rewires Carnitine‐Dependent Lipid Metabolism to Inhibit PRRSV and IAV Replication

Advanced Science, EarlyView.
NCOA4‐mediated ferritinophagy reprograms carnitine metabolism by disrupting Fe‐S cluster biogenesis, thereby establishing an iron‐lipid axis that suppresses various viruses, including PRRSV and IAV. However, viruses counteract this mechanism by degrading NCOA4.
Kaifeng Guan, Chenyang Yuan, Zekun Meng, Yanan Wang, Xueying Zhai, Chunjie Huang, Xiang Zhou, Gaiping Zhang   +7 more
wiley   +1 more source

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

Diagnosis of respiratory viruses

, 2017
Bakalářská práce se zabývá respiračními viry. V teoretické části je nejdříve vysvětleno, co jsou viry. Poté rozdělení druhů respiračních virů, z toho je největší část věnována viru chřipky, a nové respirační virové nákazy. V praktické části je pak popsán
Sluková, Marie
core