Results 161 to 170 of about 1,320,014 (285)

SCTR–Expressing Astrocyte–Serotonergic Neuron Signaling Drives Sexual Dimorphism in Depression Through KAT7/H4ac–Foxc2 Epigenetic Axis in an AMPK‐Dependent Manner

Advanced Science, EarlyView.
Astrocytic SCTR modulates depressive‐related phenotypes via AMPKα1, whereas lowered Mt1 blunts Megalin‐dependent AMPKα2 signaling in serotonergic neurons. Diminished AMPKα2 hinders KAT7 nuclear translocation, curtails KAT7 occupancy and H4K8ac at the Foxc2 promoter, and represses Foxc2 transcription, revealing cell‐type‐specific AMPK‐linked epigenetic ...
Fantao Meng, Jing Liu, Juanjuan Dai, Min Wu, Wentao Wang, Mengdi Zhang, Shujun Jiang, Yifan Cao, Lihong Xu, Lin Du, Dan Wang, Di Zhao, Gaofeng Qin, Dong Wang, Wei Li, Chen Li   +15 more
wiley   +1 more source

Respiratory viruses induce ferroptosis-like features in lung epithelial cells. [PDF]

Microbiol Spectr
Manzano-Covarrubias AL, Tosato A, Mol-van der Veen CH, Ahmadyar P, Walia J, Woest ME, De Vries-Idema J, Huckriede A, Dolga AM, Schmidt M, Rafie K.   +10 more
europepmc   +1 more source

Magnetoreceptor Promotes Hepatocellular Carcinoma Development and Blunts Sorafenib‐Induced Ferroptosis by Regulating Iron Homeostasis

Advanced Science, EarlyView.
Magnetoreceptor (MagR) regulates iron homeostasis and mitochondrial function in hepatocellular carcinoma (HCC) cells. Specifically, MagR deficiency suppresses tumor cell proliferation, migration, and invasion and enhances sorafenib‐induced ferroptosis through iron accumulation.
Tao Wang, Chenghua Song, Xin He, Mengzhou Wang, Wuming Liu, Xiaolin Wang, Yuanyuan Zhang, Jia Zhang, Lin Zhang, Dan Li, Yu Zhang, Zheng Wu, Yi Lyu, Rongqian Wu   +13 more
wiley   +1 more source

Benchmarking and optimisation of bait-capture metagenomics for sequencing of respiratory viruses at scale. [PDF]

Genome Med
Wagner J, Rajan D, Field SF, Betteridge E, Bellis K, Knoll M, Ng D, Teixeira D, Blane B, Akram A, de Sousa C, Brennan J, Aggarwal D, MacIntyre-Cockett G, Chaudron SE, Grayson N, Hyatt B, Wong A, Galvin A, Huang YL, Jackson D, Forbes M, Schwach F, Frick-Kretschmer A, Figueroa K, Lassalle F, Roberts-Sengier W, Lignes A, Novaes F, Fatima S, Howe K, Stott S, Bonsall D, Harrison EM.   +33 more
europepmc   +1 more source

ACAT1‐Mediated SP1‐K694 Lactylation Promotes M1 Macrophage Polarization via TREM1 Transcription in COPD

Advanced Science, EarlyView.
Upon cigarette smoke exposure(CSE), LDHA expression is increased in lung macrophages, promoting the conversion of pyruvate to lactate and elevating the lactylation level of SP1 at the K694 site. This, in turn, enhances SP1 enrichment at the TREM1 promoter, increases TREM1 expression, promoted M1 macrophage polarization, and triggers the secretion of ...
Ling Lin, Ping Zhang, Qing Song, Tao Li, Yuqin Zeng, Ping Chen   +5 more
wiley   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Integrated Hospital, Emergency Department, and Community Surveillance for Respiratory Viruses in Milan, Italy. [PDF]

J Med Virol
Rizzo A, Salari F, Galli C, Maffeo M, Paduraru C, Villa S, Dolci A, Pariani E, Cereda D, Milan Respiratory Viruses Surveillance Working Group.   +9 more
europepmc   +1 more source

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

Correction to: In vitro anti-influenza assessment of anionic compounds ascorbate, acetate and citrate

Virology Journal, 2022
Hadiseh Shokouhi Targhi, Parvaneh Mehrbod, Fatemeh Fotouhi, Mehriar Amininasab   +3 more
doaj   +1 more source

Circulation of Influenza and Other Respiratory Viruses in Tunisia, 2022-2023 Season. [PDF]

Influenza Other Respir Viruses
Zoubeir B, Hind B, Sonia D, Salma A, Rachel WE, Hakim EG, Rihab Y, Nacef BM, Amal M, Ichrak B, Emna E, Najla BS, El Houda GN, Radhouane T, Leila B, Chokri BH, Takoua M, Mohamed B, Mounir BJ, Khaled M, Jalila BK, Nissaf BA, Afif BS, Dhafer L, Kinda Z, Ilhem BB.   +25 more
europepmc   +1 more source