Results 141 to 150 of about 3,116,161 (404)

Rapid Tests for Influenza, Respiratory Syncytial Virus, and Other Respiratory Viruses: A Systematic Review and Meta-analysis

Clinical Infectious Diseases, 2017
Key Points This meta-analysis evaluates the diagnostic accuracy of rapid tests for the detection of respiratory viruses. Sensitivity of tests varied considerably, but specificity was high.
A. Bruning, M. Leeflang, Johanna M B W Vos, R. Spijker, M. D. de Jong, K. Wolthers, D. Pajkrt   +6 more
semanticscholar   +1 more source

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Cloned defective interfering influenza virus protects ferrets from pandemic 2009 influenza A virus and allows protective immunity to be established [PDF]

, 2012
Influenza A viruses are a major cause of morbidity and mortality in the human population, causing epidemics in the winter, and occasional worldwide pandemics.
Carroll, Miles W., Cheung, Linda, Dimmock, N. J., Dove, Brian K., Easton, A. J. (Andrew J.), Hallis, Bassam, Marriott, Anthony C., Meng, Bo, Scott, P. D. (Paul D.), Taylor, Irene   +9 more
core   +3 more sources

Additional molecular testing of saliva specimens improves the detection of respiratory viruses

Emerging Microbes &Infections, 2017
Emerging infectious diseases in humans are often caused by respiratory viruses such as pandemic or avian influenza viruses and novel coronaviruses. Microbiological testing for respiratory viruses is important for patient management, infection control and
K. K. To, Lu Lu, Cyril C Y Yip, R. Poon, Ami M. Y. Fung, Andrew K. W. Cheng, D. Lui, Deborah T Y Ho, I. Hung, Kwok-Hung Chan, K. Yuen   +10 more
semanticscholar   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

A public health perspective of SARS-CoV-2 evolution and surveillance strategies in Germany from 2020 to 2023

Communications Medicine
This review summarizes key virological parameters of SARS-CoV-2, the clinical spectrum of COVID-19, antiviral options, resistance, and the evolution of SARS-CoV-2 during the first four years of the pandemic.
Djin-Ye Oh, Martin Hölzer, Daniela Börnigen, Sofia Paraskevopoulou, Susanne Duwe, Matthias Budt, Romy Kerber, Agata Mikolajewska, Sindy Böttcher, Janna Seifried, Walter Haas, Ralf Dürrwald, Stephan Fuchs, Stefan Kröger, Max von Kleist, Thorsten Wolff, Martin Mielke, for the SARS-CoV-2 Diagnostics and Evolution Working Group at Robert Koch Institute   +17 more
doaj   +1 more source

Comparative analysis of environmental persistence of SARS-CoV-2 variants and seasonal coronaviruses

Applied and Environmental Microbiology
Conducting persistence studies of infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on environmental surfaces may require a biosafety level 3 (BSL-3) laboratory. We aimed to compare the environmental persistence of BSL-2 level human
Geun Woo Park, Boris Reija, Azaibi Tamin, Heather Hicks, Matthew Hayden Flanders, John M. Metz, Shufang Fan, Jennifer L. Harcourt, Jennifer M. Folster, Natalie Thornburg, Jan Vinjé   +10 more
doaj   +1 more source

Respiratory syncytial virus: Clinical and epidemiological pattern in pediatric patients admitted to a children’s hospital between 2000 and 2013 [PDF]

, 2014
INTRODUCTION: Respiratory syncytial virus (RSV) is the major causative organism associated with acute lower respiratory tract infections in children.The objective of this study was to describe the clinical and epidemiological pattern of RSV and identify ...
Bakir, Julia, Castellano, Verónica, Gentile, Ángela, Grobaporto, Marcela, Juárez, María del Valle, Lucion, María Florencia, Mistchenko, Alicia Susana, Romanin, Viviana Sandra, Viegas, Mariana   +8 more
core   +1 more source

Research Progress in Porcine Reproductive and Respiratory Syndrome Virus–Host Protein Interactions [PDF]

, 2022
Hang Zhang, Huiyang Sha, Limei Qin, Na Wang, Weili Kong, Liangzong Huang, Mengmeng Zhao   +6 more
openalex   +1 more source

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source