Results 81 to 90 of about 2,704,258 (334)
Frontiers in Psychiatry, 2021 Introduction: Premutation expansions (55–200 CGG repeats) of the Fragile X Mental Retardation 1 (FMR1) gene on the X chromosome are associated with a range of clinical features.
Darren R. Hocking +5 more
doaj +1 more source
Synthetic (p)ppGpp analogue is an inhibitor of stringent response in mycobacteria [PDF]
, 2017 Bacteria elicit an adaptive response against hostile conditions such as starvation and other kinds of stresses. Their ability to survive such conditions depends, in part, on stringent response pathways.
Bhardwaj, Neerupma +6 more
core +2 more sources
An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots
FEBS Letters, EarlyView.This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino +7 more
wiley +1 more source
Brain Activity Correlates With Cognitive Performance Deterioration During Sleep Deprivation
Frontiers in Neuroscience, 2019 We studied the correlation between oscillatory brain activity and performance in healthy subjects performing the error awareness task (EAT) every 2 h, for 24 h. In the EAT, subjects were shown on a screen the names of colors and were asked to press a key
Hugo F. Posada-Quintero +4 more
doaj +1 more source
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
Brain SciencesBackground: Amphetamines increase dopamine levels in mid-brain regions which, in turn, impact top-down executive function. Repeated exposure is linked to substance use disorders.
Antoinette Poulton +4 more
doaj +1 more source
Executive control and felt concentrative engagement following intensive meditation training
Frontiers in Human Neuroscience, 2013 Various forms of mental training have been shown to improve performance on cognitively demanding tasks. Individuals trained in meditative practices, for example, show generalized improvements on a variety of tasks assessing attentional performance.
Anthony Paul Zanesco +7 more
doaj +1 more source
Response Inhibition in Smokers
Advances in Psychological Science, 2015 近期研究发现，吸烟会使个体的反应抑制能力受到一定程度的影响。与不吸烟的健康人群相比，吸烟者在测量反应抑制能力的Go/NoGo任务和Stop-Signal任务上的虚报率较高，反应时间较长；吸烟者的反应抑制能力在反应抑制加工阶段受到影响，而在冲突监控阶段并未与正常被试表现出差异；另外，研究还发现，与不吸烟者相比，吸烟者左侧丘脑、左侧额中回和左侧前扣带回灰质体积较小。尼古丁的摄入对前额叶和中脑边缘多巴胺系统的影响可能是导致吸烟者反应抑制能力受到影响的原因。但是，一些研究并未发现吸烟对反应抑制能力存在影响，这可能与实验任务以及研究对象的选取有关。比较不同香烟剥夺状态下个体的反应抑制能力、比较吸烟者与其他药物成瘾者（酒精、毒品）反应抑制能力的差异并且比较使用双选择oddball范式与 Go/NoGo 任务和 ...
Xin ZHAO +3 more
openaire +1 more source
p185(BCR/ABL) has a lower sensitivity than p210(BCR/ABL) to the allosteric inhibitor GNF-2 in Philadelphia chromosome-positive acute lymphatic leukemia [PDF]
, 2011 Background: The t(9;22) translocation leads to the formation of the chimeric breakpoint cluster region/c-abl oncogene 1 (BCR/ABL) fusion gene on der22, the Philadelphia chromosome.
Mahajna, Jamal +5 more
core +2 more sources
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source