Results 81 to 90 of about 1,615,018 (245)

Hepatic response criteria in light chain amyloidosis: a multicenter validation study

Haematologica
Liver involvement in light chain amyloidosis (AL) is seen in 10-20% of patients and is associated with poor prognosis. The goal of this study was to assess the prognostic impact of the hepatic response criteria.
Eli Muchtar, Giovanni Palladini, Stefan Schonland, Susan Geyer, Katharine E. Dooley, Angela Dispenzieri, Brendan Wisniowski, Giampaolo Merlini, Paolo Milani, Ute Hegenbart, Tobias Dittrich, Efstathios Kastritis, Meletios A. Dimopoulos, Vaishali Sanchorawala, Raphael Szalat, Michaela Liedtke, Mani Gupta, Heather Landau, Suzanne Lentzsch, Michael S. Hughes, Maria Teresa Cibeira, Joan Blade, Shaji K. Kumar, Ashutosh Wechalekar, Morie A. Gertz   +24 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A Simple Response Evaluation Method for Base-Isolation Building-Connection Hybrid Structural System under Long-Period and Long-Duration Ground Motion

Frontiers in Built Environment, 2018
An innovative hybrid control building system of base-isolation and building-connection has been proposed in the previous study. This system has two advantages, (i) to resist an impulsive earthquake input through the base-isolation system and (ii) to ...
Kohei Hayashi, Kohei Fujita, Masaaki Tsuji, Izuru Takewaki   +3 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Energy Dissipation and Local, Story, and Global Ductility Reduction Factors in Steel Frames under Vibrations Produced by Earthquakes

Shock and Vibration, 2018
Ductility plays a central role in seismic analysis and design of steel buildings. A numerical investigation regarding the evaluation of energy dissipation, ductility, and ductility reduction factors for local, story, and global structural levels is ...
Alfredo Reyes-Salazar, Edén Bojórquez, Juan Bojorquez, Federico Valenzuela-Beltran, Mario D. Llanes-Tizoc   +4 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

A transformer-based embedding approach to developing short-form psychological measures

Frontiers in Psychology
IntroductionDeveloping short-form psychological measures is essential for reducing respondent burden, saving time, and conserving resources. However, existing short-form development approaches typically require full-scale administration and rely on ...
Se-Jin Jung, Jang-Won Seo
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source