Results 81 to 90 of about 1,717,018 (297)

Uninephrectomy in rats on a fixed food intake potentiates both anorexia and circulating cytokine subsets in response to LPS.

Frontiers in Immunology, 2015
Recent human studies have suggested that mild reduction in kidney function can alter immune response and increase susceptibility to infection. The role of mild reduction in kidney function in altering susceptibility to bacterial lipopolysaccharide (LPS ...
Denis eArsenijevic, Denis eArsenijevic, Jean-Pierre eMontani, Jean-Pierre eMontani   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

An optimal electricity consumption strategy for steel enterprises with short processes in the context of low-carbon DR

Zhejiang dianli
Currently， large industrial enterprises， such as steel mills， have reduced electricity costs by participating in demand response programs； however， they have not yet achieved their carbon and emission reduction goals.
YAN Yue, FENG Haoran, GUO Yihan, CHEN Xiang, SONG Jinwei, ZHANG Shize, HE Qi   +6 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients

, 2001
Patients with scleroderma receiving Iloprost as a treatment for severe Raynaud's phenomenon report a reduction in skin tightness, suggesting that this drug inhibits skin fibrosis.
Stratton, R, Thomas Haberberger, Carol M. Black, Haberberger, T, Xu Shiwen, Martini, G, Holmes, A, Alan Holmes, Andrew Leask, Shiwen, X, David Abraham, Black, CM, Leask, A, Martin, GR, Abraham, D, George R. Martin, Richard Stratton, Giorgia Martini   +17 more
core   +1 more source

Influence of soil type on damping reduction factor: A stochastic analysis based on peak theory

, 2018
Damping reduction factor plays a central role both in scientific literature and seismic codes, but still now proposed formulations show a quite large scatter.
Fiore, Alessandra, Bruno Briseghella, Alessandra Fiore, Greco, Rita, Rita Greco, Briseghella, Bruno   +5 more
core   +2 more sources

Differential Regulation of the Heat Shock Factor 1 and DAF-16 by Neuronal nhl-1 in the Nematode C. elegans

Cell Reports, 2014
In the nematode Caenorhabditis elegans, insulin/insulin-like growth factor 1 (IGF-1) signaling (IIS) reduction hyperactivates the transcription factors DAF-16 and heat shock factor 1 (HSF-1), creating long-lived, stress-resistant worms that are protected
Yuli Volovik, Lorna Moll, Filipa Carvalhal Marques, Moria Maman, Michal Bejerano-Sagie, Ehud Cohen   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Seismic performance evaluation of multi-storied RC structures by nonlinear static analysis

Results in Engineering
There is no proper specification about response reduction factor for various configured structures in the latest version of Bangladesh National Building Code (BNBC 2020).
Md. Foisal Haque, Md. Mahmodul Hasan Rahat, Md. Mozammel Hoque   +2 more
doaj   +1 more source

Review and Derivation of Areal Reduction Factor in Malaysia with Response to Changing Climate

KSCE Journal of Civil Engineering, 2018
This study presents the reviews and derivations of ARF for storm design applications in Malaysia. Considering that present rainfall characteristics may change due to climate change, rainfall time series data of the selected rainfall interval of nine rainfall stations in Kuala Lumpur were examined by several homogeneity tests and trend test to determine
Kahhoong Kok, Wansik Yu, Lariyah Mohd Sidek, Kwansue Jung   +3 more
openaire   +1 more source