Results 71 to 80 of about 841,738 (326)
, 2015 The purpose of this paper is to examine various DoE methods for uncertainty quantification of production forecast during reservoir management. Considering all uncertainties for analysis can be time consuming and expensive.
A. Arinkoola, D. Ogbe
semanticscholar +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Optimum Simplex Lattice Designs of Low Order Multiresponse Surface Model by D-Optimum Criterion
Jurnal Ilmu Dasar, 2010 Simplex lattice design is a part of mixture designs has patterns simplex {q, m} where q is number of factors andm is degree of polynomial. If entangling a number of the response variables which measured from a number offactors called the multiresponse ...
Ruslan Ruslan +3 more
doaj
Advanced Electrical and Optical Microsystems for Biointerfacing
Advanced Intelligent Systems, 2020 Electrical and optical biointerfaces have contributed considerably to understanding biological systems. Recent advances in biocompatible materials, structure designs, and fabrication techniques have established flexible and minimally invasive electronic ...
Sofian N. Obaid, Zhiyuan Chen, Luyao Lu
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
International Journal of Applied Mechanics and Engineering, 2013 A design optimization of a staggered pin fin heat sink made of a thermally conductive polymer is presented. The influence of several design parameters like the pin fin height, the diameter, or the number of pins on thermal efficiency of the natural ...
K. Kasza +2 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Optimization of Adsorption Parameters for Ultra-Fine Calcite Using a Box-Behnken Experimental Design
Open Chemistry, 2018 Removal of heavy metals from wastewater is a significant issue because it prevents environmental-based concerns and impacts a large number of diseases and disorders.
Uçurum Metin +4 more
doaj +1 more source