Results 81 to 90 of about 657,782 (299)
Experimental Design for Sensitivity Analysis, Optimization and Validation of Simulation Models [PDF]
This chapter gives a survey on the use of statistical designs for what-if analysis in simula- tion, including sensitivity analysis, optimization, and validation/verification. Sensitivity analysis is divided into two phases.
Kleijnen, J.P.C.
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Optimization of Adsorption Parameters for Ultra-Fine Calcite Using a Box-Behnken Experimental Design
Open Chemistry, 2018 Removal of heavy metals from wastewater is a significant issue because it prevents environmental-based concerns and impacts a large number of diseases and disorders.
Uçurum Metin +4 more
doaj +1 more source
International Journal of Applied Mechanics and Engineering, 2013 A design optimization of a staggered pin fin heat sink made of a thermally conductive polymer is presented. The influence of several design parameters like the pin fin height, the diameter, or the number of pins on thermal efficiency of the natural ...
K. Kasza +2 more
doaj +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Creating double negative index materials using the Babinet principle with one metasurface
, 2013 Metamaterials are patterned metallic structures which permit access to a novel electromagnetic response, negative index of refraction, impossible to achieve with naturally occurring materials.
Koschny, Thomas +2 more
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Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Competitive Comparison of Optimal Designs of Experiments for Sampling-based Sensitivity Analysis
, 2012 Nowadays, the numerical models of real-world structures are more precise, more complex and, of course, more time-consuming. Despite the growth of a computational effort, the exploration of model behaviour remains a complex task.
Janouchova, Eliska, Kucerova, Anna
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Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Response Surface Splitplot Designs: A Literature Review [PDF]
The fundamental principles of experiment design are factorization, replication, randomization, and local control of error. In many industrial experiments, however, departure from these principles is commonplace.
Cortes, Luis A. +2 more
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