Results 91 to 100 of about 3,378,607 (346)

Comparison of response surface methodology and the Nelder and Mead simplex method for optimization in microsimulation models [PDF]

Microsimulation models are increasingly used in the evaluation of cancer screening. Latent parameters of such models can be estimated by optimization of the goodness-of-fit.
Dekker, R., Habbema, J.D.F., Neddermeijer, H.G., Oortmarssen, G.J. van, Piersma, N.   +4 more
core   +1 more source

Isogeometric analysis applied to frictionless large deformation elastoplastic contact [PDF]

, 2013
This paper focuses on the application of isogeometric analysis to model frictionless large deformation contact between deformable bodies and rigid surfaces that may be represented by analytical functions. The contact constraints are satisfied exactly with
Kvamsdal, Trond, Mathisen, Kjell M., Okstad, Knut M., Raknes, Siv B.   +3 more
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Optimal extraction of a polysaccharide with antioxidant and hypoglycemic activities from the root of Radix Puerariae lobatae (Willd.) Ohwi

CyTA - Journal of Food
Radix Pueraria lobata has been recognized as a medicine and functional food, whose polysaccharide is its main bioactive component. In this study, we employed the response surface method to optimize the extraction of a polysaccharide from Radix Puerariae ...
Jingjing Fang, Yijun Zhang, Yuqing Liu, Wen Cao, Qiuyue Lv, Jiangping Wu, Guodong Wang, Jun Han   +7 more
doaj   +1 more source

ON THE BOOTSTRAP METHOD OF ESTIMATION OF RESPONSE SURFACE FUNCTION [PDF]

, 2014
Nowadays, in many fields of science it is necessary to carry out miscellaneous analyses using classical statistical methods, which usually have correct assumptions.
Szerszunowicz, Małgorzata
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Terahertz Kerr and Reflectivity Measurements on the Topological Insulator Bi2Se3

, 2010
We report the first terahertz Kerr measurements on bulk crystals of the topological insulator Bi2Se3. At T=10K and fields up to 8T, the real and imaginary Kerr angle and reflectance measurements utilizing both linearly and circularly polarized incident ...
Butch, N. P., Drew, H. D., Jenkins, G. S., Paglione, J., Schmadel, D. C., Sushkov, A. B., Syers, P.   +6 more
core   +1 more source

Multiresponse Optimization for a Novel Compliant Z-Stage by a Hybridization of Response Surface Method and Whale Optimization Algorithm [PDF]

, 2021
Minh Phung Dang, Hieu Giang Le, Ngoc N. Trung Le, Ngoc Le Chau, Thanh-Phong Dao   +4 more
openalex   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source