Results 61 to 70 of about 3,421,628 (295)
From responsible research to responsible innovation: challenges in implementation
Engineering Biology, 2017 This study proposes a new approach to the responsible development of innovative products, processes and services by companies and organisations operating in the bioeconomy and related industry sectors.
Joyce Tait
doaj +1 more source
, 2018 Presentation on the 6 deficits of the global research and innovation system and the case for responsible ...
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Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Marine DrugsThe convergence of marine sciences and medical studies has the potential for substantial advances in healthcare. This study uses bibliometric and topic modeling studies to map the progression of research themes from 2000 to 2023, with an emphasis on the ...
Mehdi Zamani +4 more
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Responsible research and innovation
This chapter summarises the history and significance of the concept of responsible research and innovation (RRI) in Europe and the emergence of a linked community of practice in research and policy arenas.
Richard Woolley +3 more
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Responsible retrospection: adapting responsible innovation to the liminal innovation of ICTs
Journal of Responsible InnovationICTs are ubiquitous in today's digitised societies, but Responsible Innovation (RI) approaches are ill-equipped to address the liminal nature of ICT innovation. ICTs remain malleable after their diffusion.
Ivan Veul, Lotte Krabbenborg
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Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source