Results 51 to 60 of about 1,109,777 (250)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

The effects of experimentally induced hyperthyroidism on the diving physiology of harbor seals (Phoca vitulina)

Frontiers in Physiology, 2012
Many phocid seals are expert divers that remain submerged longer than expected based on estimates of oxygen storage and utilization. This discrepancy is most likely due to an overestimation of diving metabolic rate.
Gundula M Weingartner, Sheila J. Thornton, Russel D Andrews, Russel D Andrews, Manfred R. Enstipp, Agnieszka eDorota Barts, Peter W. Hochachka   +6 more
doaj   +1 more source

RNA-seq analysis to identify genes related to resting egg production of panarctic Daphnia pulex

BMC Genomics, 2023
Background The genus Daphnia switches its reproductive mode from subitaneous egg production to resting egg production in response to environmental stimuli. Although this life history trait is essential for surviving unsuitable environments, the molecular
Natsumi Maruoka, Takashi Makino, Jotaro Urabe   +2 more
doaj   +1 more source

Vascular control of resting metabolism in muscle

, 1996
Vascular Control of Resting Metabolism in Muscle Whilst it is generally accepted that the metabolic rate of muscle will determine its own blood flow by autoregulation the reverse relationship of blood flow controlling metabolism is less understood ...
Steen, J. T (15941186)
core   +1 more source

Avian thermoregulation in the heat: resting metabolism, evaporative cooling, and heat tolerance in Sonoran Desert songbirds [PDF]

, 2017
We examined thermoregulatory performance in seven Sonoran Desert passerine bird species varying in body mass from 10 to 70g – Lesser Goldfinch, House Finch, Pyrrhuloxia, Cactus Wren, Northern Cardinal, Abert's Towhee and Curve-billed Thrasher. Using flow-
Eric Krabbe Smith, Smith, Eric Krabbe, Blair O. Wolf, Jacqueline J. O'Neill, O’Neill, Jacqueline J., McKechnie, Andrew E., Gerson, Alexander R., Alexander R. Gerson, Wolf, Blair O., Andrew E. McKechnie   +9 more
core   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Relations between BOLD fMRI-derived resting brain activity and cerebral blood flow. [PDF]

PLoS ONE, 2012
Consistent resting brain activity patterns have been repeatedly demonstrated using measures derived from resting BOLD fMRI data. While those metrics are presumed to reflect underlying spontaneous brain activity (SBA), it is challenging to prove that ...
Zhengjun Li, Yisheng Zhu, Anna Rose Childress, John A Detre, Ze Wang   +4 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source