Results 61 to 70 of about 1,109,777 (250)

8-Oxoguanine DNA glycosylase (OGG1) deficiency increases susceptibility to obesity and metabolic dysfunction. [PDF]

PLoS ONE, 2012
Oxidative damage to DNA is mainly repaired via base excision repair, a pathway that is catalyzed by DNA glycosylases such as 8-oxoguanine DNA glycosylase (OGG1). While OGG1 has been implicated in maintaining genomic integrity and preventing tumorigenesis,
Harini Sampath, Vladimir Vartanian, M Rick Rollins, Kunihiko Sakumi, Yusaku Nakabeppu, R Stephen Lloyd   +5 more
doaj   +1 more source

Frequency-Dependent Relationship Between Resting-State fMRI and Glucose Metabolism in the Elderly [PDF]

, 2019
Both glucose metabolism and resting-state fMRI (RS-fMRI) signal reflect hemodynamic features. The objective of this study was to investigate their relationship in the resting-state in healthy elderly participants (n = 18).
Su, Hui, Shi, Shenxun, Zang, Yu-Feng, Jia, Xize, Ge, Jingjie, Wu, Ping, Shi, Kuangyu, Jiang, Chengfeng, Zuo, Chuantao, Jiao, Fangyang, Gao, Zhongzhan, Guan, Yihui   +11 more
core   +2 more sources

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Metabolism

, 2017
Metabolism is driven by redox reactions, in which part of the difference in potential energy between the electron donor and acceptor is used by the organism for its life processes (with the remainder being dissipated as heat).
Andrew Clarke
core   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Altered coupling between resting‐state glucose metabolism and functional activity in epilepsy

Annals of Clinical and Translational Neurology, 2020
Objective Altered functional activities and hypometabolism have been found in medial temporal lobe epilepsy patients with hippocampal sclerosis (mTLE‐HS).
Jingjuan Wang, Yi Shan, Jindong Dai, Bixiao Cui, Kun Shang, Hongwei Yang, Zhongwei Chen, Baoci Shan, Guoguang Zhao, Jie Lu   +9 more
doaj   +1 more source

Resting-state functional connectivity matrices

, 2015
Resting-state functional connectivity matrices, in MATLAB data format (.mat)
Danielle S. Bassett (215337), Bassett, Danielle S., Michael W. Cole (833026), Cole, Michael W., Sharon L. Thompson-Schill (506355), Marcelo G. Mattar (833025), Mattar, Marcelo G., Thompson-Schill, Sharon L.   +7 more
core   +1 more source

A nationwide student survey on biochemistry learning resources in Italy

FEBS Open Bio, EarlyView.
We conducted a survey among Italian university students to investigate their preferred study materials for biochemistry. We then analyzed the collected data to identify these materials. This information may be valuable to the Biochemistry educational community. The graphical abstract was created with Claude (Opus 5.5; Anthropic, 2026).
Anna Marabotti, Ivano Eberini, Maria Luisa Genova, Francesca Mensitieri, Francesco Malatesta   +4 more
wiley   +1 more source

Effect of menstrual cycle on resting metabolism: A systematic review and meta-analysis.

PLoS ONE, 2020
BackgroundThe need to control for the potential influence of menstrual cycle phase on resting metabolism (RMR) places a burden on research participants who must self-report onset of menstruation and researchers who must schedule metabolic testing ...
Melissa J Benton, Andrea M Hutchins, J Jay Dawes   +2 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source