Results 81 to 90 of about 1,196,125 (293)

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

Glucose metabolism and autonomic function in healthy individuals and patients with type 2 diabetes mellitus at rest and during exercise

Experimental Physiology
Autonomic dysfunction is a common complication of type 2 diabetes mellitus (T2DM). However, the character of dysfunction varies in different reports. Differences in measurement methodology and complications might have influenced the inconsistent results.
Takuto Hamaoka, Urs A. Leuenberger, Rachel C. Drew, Matthew Murray, Cheryl Blaha, Jonathan Carter Luck, Lawrence I. Sinoway, Jian Cui   +7 more
doaj   +1 more source

Resting-state functional connectivity matrices

, 2015
Resting-state functional connectivity matrices, in MATLAB data format (.mat)
Danielle S. Bassett (215337), Bassett, Danielle S., Michael W. Cole (833026), Cole, Michael W., Sharon L. Thompson-Schill (506355), Marcelo G. Mattar (833025), Mattar, Marcelo G., Thompson-Schill, Sharon L.   +7 more
core   +1 more source

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

Diurnal Variations in Resting Metabolism

Eiyo To Shokuryo, 1974
基礎代謝測定時と同じ条件の下で測定された臥位安静時代謝は体温その他, 身体的機能の日内変動や代謝過程の推移に伴って, どのような逐時的変化を示すかを追求し, 大要次のような結果を得た。1) 臥位安静時代謝は基礎代謝測定後逐時的に増高し, 16時, 19時および22時にはそれぞれ10%, 17%, および20%の亢進を示した。 この代謝亢進は体温の上昇度やRQの低下度からある程度推定できるが, 19時以後では全血比重や血中ケトン体が増大することにより推定値よりも高い代謝亢進を示した。これは脱水や脂肪の異常代謝によるストレスなどによるものではないかと考える。2) 臥位安静時代謝とその逐時的変化を招来すると考えられる諸要因との間には時系列的に次のような相関関係がみられた。血漿FFA0.98 最高血圧0 ...
OHNAKA, Masaharu, MOURI, Takaji, USUI, Humio   +2 more
openaire   +2 more sources

Resting-state network organisation in children with traumatic brain injury

, 2023
Children with traumatic brain injury are at risk of neurocognitive and behavioural impairment. Although there is evidence for abnormal brain activity in resting-state networks after TBI, the role of resting-state network organisation in paediatric TBI ...
C C Kooper (13309017), P J W Pouwels (13309020), M Königs (13309032), Edith Botchway (13068198), M Engelen (13309026), J Oosterlaan (13309029), H Bruining (13309023)   +6 more
core  

Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son, Inyoung Hwang, Sang Won Lee, Yun Kim   +3 more
wiley   +1 more source

Metabolic and Fluid Biomarkers Support Microglia Activation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis is an incurable neurodegenerative disease involving motor neuron degeneration and metabolic and immune dysfunction. We combined clinical data, cerebrospinal fluid biomarkers and fluorodeoxyglucose positron emission tomography with magnetic resonance imaging to investigate the role of reactive microglia in disease ...
Matteo Zanovello, Francesca Serani, Alen Bebeti, Federica Paredi, Giulia Quadrio, Andrea Fortuna, Giacomo Maria Minicuci, Elena Pegoraro, Annachiara Cagnin, Diego Cecchin, Gianni Sorarù   +10 more
wiley   +1 more source

Neuroimaging evaluation of the long term impact of a novel paired meditation practice on brain function

Frontiers in Neuroimaging
BackgroundA growing number of advanced neuroimaging studies have compared brain structure and function in long term meditators to non-meditators. The goal is to determine if there may be long term effects on the brain from practicing meditation.
Andrew B. Newberg, Andrew B. Newberg, Nancy A. Wintering, Chloe Hriso, Faezeh Vedaei, Sara Gottfried, Reneita Ross   +6 more
doaj   +1 more source