Results 101 to 110 of about 1,147,765 (344)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Decoupling Distribution of n-Alkanes in Aeolian Sand and Vegetation of the Northern Ulan Buh Desert, China: Insight into Organic Matter Preservation in Arid Regions

Plants
Fallen leaves and their decomposition directly deposit leaf wax n-alkanes into sediments, which can be used to identify local flora. These n-alkanes are important for studying past vegetation and climate, but their distribution in sediments must be known.
Shangzhe Zhou, Lei Xi, Mengchun Cui, Guipeng Cui, Pan Gao, Jinlei Zhu, Weiyuan Kong, Yufu Jia, Qi Lu   +8 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Long-Term Electroclinical and Employment Follow up in Temporal Lobe Epilepsy Surgery. A Cuban Comprehensive Epilepsy Surgery Program

Behavioral Sciences, 2018
The purpose of this paper is to present a long- term electroclinical and employment follow up in temporal lobe epilepsy (TLE) patients in a comprehensive epilepsy surgery program.
Lilia Maria Morales Chacón, Ivan Garcia Maeso, Margarita M. Baez Martin, Juan E. Bender del Busto, María Eugenia García Navarro, Nelson Quintanal Cordero, Bárbara Estupiñan Díaz, Lourdes Lorigados Pedre, Ricardo Valdés Yerena, Judith Gonzalez, Randy Garbey Fernandez, Abel Sánchez Coroneux   +11 more
doaj   +1 more source

Clinical performance of one shade universal composite resin and nanohybrid composite resin as full coronal esthetic restorations in primary maxillary incisors: A randomized controlled trial

, 2022
KakarlaSri RojaRamya, Zulekha, C Vinay, KS Uloopi, Penmatsa Chaitanya, MV Ramesh   +5 more
openalex   +1 more source

Economically viable forest restoration in shifting cultivation landscapes [PDF]

, 2020
Oscar Morton, Joli R. Borah, David P. Edwards   +2 more
openalex   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Optogenetic Vision Restoration Using Rhodopsin for Enhanced Sensitivity [PDF]

, 2015
Benjamin M. Gaub, Michael H. Berry, Amy Holt, Ehud Y. Isacoff, John G. Flannery   +4 more
openalex   +1 more source

Restoration of Corneal Transparency in a Patient with Corneal Scarring Using Mesenchyme Stem Cells: A Case Report [PDF]

, 2023
Shahrokh Ramin, Ali Abbasi, Masoumeh Ahadi, Lina Moallemi Rad, Zahra Fallah Tafti   +4 more
openalex   +1 more source