Results 61 to 70 of about 14,052 (291)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Restorative justice, as a restorative action, in school coexistence processes: a systematic review
, 2023 La convivencia se ha convertido en la dificultad más evidente en los entornos escolares, requiere intervenciones que coadyuven a prevenir los conflictos, atacando sus causas para solucionar problemas de la interacción escolar.
Hernández Roa, Ginna Paola +1 more
core
Frontiers in Psychology, 2019 Immersive virtual environments (IVEs) technology has emerged as a valuable tool to environmental psychology research in general, and specifically to studies of human–nature interactions.
Sigbjørn Litleskare, Giovanna Calogiuri
doaj +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
29th Annual Conference of the Australasian Society for Computers in Learning in Tertiary Education (ASCILITE 2012) [PDF]
, 2012 Immersive natural environments provide a means of restoration for adults and may present benefits for pre-service teachers who are unfamiliar with the natural world.
Farley, Helen +2 more
core
High-fidelity immersive virtual reality environments for gait rehabilitation exergames
Frontiers in Virtual RealityIntroductionVirtual reality (VR) used for healthcare, particularly through exergames, is promising for improving therapeutic outcomes. However, effectively engaging patients and providing realistic environments for everyday situations remain major ...
Laura Schalbetter +3 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
A Review of Psychological Literature on the Health and Wellbeing Benefits of Biophilic Design
Buildings, 2015 Biophilic design has received increasing attention as a design philosophy in recent years. This review paper focused on the three Biophilic design categories as proposed by Stephen Kellert and Elizabeth Calabrese in “The Practice of Biophilic Design ...
Kaitlyn Gillis, Birgitta Gatersleben
doaj +1 more source