Results 101 to 110 of about 5,596,824 (289)

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Physical education down under: Fusion or confusion [PDF]

, 2007
At the International Council for Health, Physical Education, Recreation, Sport and Dance (ICHPER-SD) Conference held in Wellington in October 2006, the authors presented a keynote titled: Physical Education Down Under: Fusion or Confusion.
Culpan, Ian, Grant, Bevan C.
core  

Polymorphic Superparaelectric Engineering Boosting Energy Storage Capacity in BaTiO3‐Based Ceramics

Advanced Science, EarlyView.
Herein, Ca2+ incorporation promotes the coexistence of CaTiO3‐/BaTiO3‐derived paraferroelectric states, stabilizing cubic‐orthorhombic‐tetragonal polymorphic superparaelectric phases. This minimizes polarization energy barriers, facilitating full polarization saturation without compromising efficiency.
Pan Liu, Xiang Ren, Jin Qian, Haihua Huang, Peng Li, Peng Fu, Jigong Hao, Huarong Zeng, Wei Li, Zhenxiang Cheng   +9 more
wiley   +1 more source

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions

Advanced Science, EarlyView.
This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang   +8 more
wiley   +1 more source

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

Promoting Post-Restraint Patient Debriefing in an Acute Psychiatric Inpatient setting

BJPsych Open
Aims Controlled physical restraint is a commonly used, but controversial practice in inpatient psychiatric settings, at times bringing psychiatric practice into potential conflict with accepted medical ethical standards for preserving autonomy and ...
Harry Jackson, Munzir Quraishy, Maya Mendoza, Alex Berry   +3 more
doaj   +1 more source

Controllable Carbon Shell Encapsulation via Rapid Joule Heating Calcination for High‐Performance Asymmetric Supercapacitor With Suppressed Self‐Discharge and Robust Cycling Stability

Advanced Science, EarlyView.
The H‐Fe3O4@C negative electrode and H‐NiCo2S4@C positive electrode are designed through a controllable carbon shell encapsulation strategy. The as‐constructed asymmetric supercapacitor presents robust cycling stability with 93.7% capacity retention after 25 000 cycles.
Qiang Zhou, Zheng Yang, Zhen Cao, Xulan Zheng, Xiao Yan, Yunsong Li, Xinsheng Zhao, Yuxiao Lin, Xiaoxiao Li   +8 more
wiley   +1 more source

Environmental restraint: A hidden risk factor for stress-induced depression in rats

IBRO Neuroscience Reports
Little is known about the impact of environmental restraint, characterized by limited space and a lack of stimulating elements, on adult mental and physical health.
Hiroko Mochizuki-Kawai, Seita Nakazawa, Hideaki Oike, Hiromi Kimoto, Satoru Tomita, Michimasa Toyoshima, Tingbi Xiong, Kazuo Yamada   +7 more
doaj   +1 more source

Synergistic Effect of Gradient Conductivity and Gradient Microstructures Enabled Ultrasensitive and Ultrabroad Linear Flexible Tactile Sensors

Advanced Science, EarlyView.
A design of double gradient effect is proposed to resolve the contradictory optimization on sensitivity and linearity of piezoresistive tactile sensors. The ultrawide linearity is realized by the sequential trigger of pressure‐induced gradient conductivity‐enabled linear current owing to the gradient microstructures.
Yao Fang, Yiwei Wang, Bing Zheng, Liu Yang, Jingyi Yue, Qian Zhou, Jinrong Huang, Yongyun Mao, Qian Li, Jifei Wang, Dongsheng Tang, Yuxin Tang, Bingpu Zhou, Bing Ji   +13 more
wiley   +1 more source

AI‐Assisted Digital Single‐Molecule Activity Tracker for Decoupling Intrinsic Heterogeneity from Photo‐Oxidative Damage in High‐Photon‐Flux Enzymology

Advanced Science, EarlyView.
Employing a digital single‐molecule activity tracker (dSMAT), this research demonstrates that high‐photon‐flux irradiation drives progressive oxidative scarring in polymerases. Unlike simple thermal denaturation, real‐time kinetic tracking dynamically visualizes enzymes degrading into multiple impaired subpopulations.
Anran Zheng, Qi Yang, Jinze Li, Fuqiang Ma, Xuefeng Wang, Zhen Guo, Chuanyu Li, Dongshu Li, Jia Yao, Zhiqi Zhang, Wei Zhang, Lianqun Zhou   +11 more
wiley   +1 more source