Results 191 to 200 of about 228,478 (241)

Correction: A novel SfaNI-like restriction-modification system in Caldicellulosiruptor extents the genetic engineering toolbox for this genus. [PDF]

PLoS One
Swinnen S, Zurek C, Krämer M, Heger RM, Domeyer JE, Ziegler J, Svetlitchnyi VA, Läufer A.   +7 more
europepmc   +1 more source

Structure and mutagenesis of the DNA modification-dependent restriction endonuclease AspBHI [PDF]

, 2014
J.R. Horton, R. L. Nugent, Andrew Li, Megumu Mabuchi, Alexey Fomenkov, Devora Cohen-Karni, Rose M. Griggs, Xing Zhang, Geoffrey G. Wilson, Yu Zheng, Shuang-yong Xu, Xiaodong Cheng   +11 more
openalex   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Modeling and bioinformatics of bacterial immune systems: understanding regulation of CRISPR/Cas and restriction-modification systems

, 2017
Jelena Guzina, Andjela Rodic, Bojana Ilic, Marko Đorđević   +3 more
openalex   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Correction to 'The early injected genomic region determines sensitivity to Type I restriction-modification defence against Autographiviridae phages'. [PDF]

Nucleic Acids Res
europepmc   +1 more source

Highly efficient CRISPR-Cas9 base editing in <i>Bifidobacterium</i> with bypass of restriction modification systems. [PDF]

Appl Environ Microbiol
Lin H-C, Hsiao W-C, Hsu Y-C, Lin M-C, Hsu C-C, Zhang MM.   +5 more
europepmc   +1 more source

Integrating evolutionary and molecular microbiology to characterise host-specific genome defence associated with a novel Type IV Restriction-Modification system

Tanya Horne
openalex   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Cryo-EM structures of DNA-free and DNA-bound BsaXI: architecture of a Type IIB restriction-modification enzyme. [PDF]

Nucleic Acids Res
Shen BW, Heiter D, Yang W, Xu SY, Stoddard BL.   +4 more
europepmc   +1 more source